Results 231 to 240 of about 10,651,893 (289)

Targeting cancer-associated fibroblasts: therapeutic strategies, translational challenges, and future perspectives. [PDF]

J Hematol Oncol
Jiang Y, Ding B, Yin H, Hua Y, Ma N, Hu P, Deng J, Wu FG, Shen Y.   +8 more
europepmc   +1 more source

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source

Comparative Analysis of Primary and Liver Fibroblasts Reveals MET as a Potent Target in Pancreatic Cancer Metastasis. [PDF]

Cell Mol Gastroenterol Hepatol
Singh R, Yousefian N, Allen WM, Silva AD, Anaraki C, Michels AK, Calderon S, Loveless IM, Rastelli D, George A, Aldakkak M, McDonald OG, Lytle NK, Morton JP, Ayabe RI, Imagawa D, Jutric Z, Martinez TF, Steele NG, Halbrook CJ.   +19 more
europepmc   +1 more source

Nrsn1–Smarcc1 Coupling Regulates Neural Stem Cell Differentiation and Chronic‐phase Recovery After Ischemic Stroke

Advanced Science, EarlyView.
In the post‐stroke brain, Foxa2 induces the transcriptional upregulation of Nrsn1 in NSCs. Nrsn1 functionally couples with Smarcc1, modulating its nuclear availability and protein abundance, thereby influencing Smarcc1‐associated regulatory programs linked to neuronal lineage commitment. Through this coupling, Nrsn1 promotes the differentiation of NSCs
Ruolin Zhang, Chang Liu, Yuneng Zhou, Kaichen Zhao, Muyang Li, Bingcheng Cai, Ying Wang, Zhiyuan Yuan, Zhaoxin Liu, Zilong Yuan, Yao Xiao, Peiyang Zhou, Ke Shui, Wendai Bao, Min Zhang, Jun Qin, Jun Chen, Xin Yang, Zhiqiang Dong   +18 more
wiley   +1 more source

TAK1 signaling in fibrosis: insights from systemic sclerosis. [PDF]

Front Immunol
Scarneo S, Freeze R, Bhattacharyya S, Varga J.   +3 more
europepmc   +1 more source

FGFR signaling and apoptotic regulation in cancer: links to immune evasion, therapeutic resistance, and treatment re-engagement. [PDF]

Front Immunol
Hu Y, Zhang X, Liu W, Wei Y, Xue J, Ma X, Cao Y, Li P.   +7 more
europepmc   +1 more source

Healthy Participant Versus Patient Selection for Clinical Pharmacology Studies in Small-Molecule Oncology Drug Development. [PDF]

Clin Transl Sci
Gupta P, Hu Z, Zhu L, Hamuro L.
europepmc   +1 more source

Active Peyronie's disease as an early antifibrotic treatment window: a translational review. [PDF]

Sex Med
Broul M, Liegertová M, Hujová A, Vostrý M.   +3 more
europepmc   +1 more source

Discovery of a covalent FGFR2-selective inhibitor overcoming clinically-acquired resistance mutations. [PDF]

Nat Commun
Huang X, Cao X, Zheng L, Luo R, Fang Z, Liang Y, Zhu Y, Chen S, Zheng L, Xu Z, Li X, Liang G, Chen L.   +12 more
europepmc   +1 more source