Results 341 to 350 of about 2,052,125 (407)
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CNS Injuries: Cellular Responses and Pharmacological Strategies, 1998
Christof Meisinger +2 more
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Christof Meisinger +2 more
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British Medical Bulletin, 1989
The existence of fibroblast growth factors (FGFs) was proposed over 40 years ago to account for the ability of tissue extracts to stimulate fibroblast proliferation. In the 1970s it became clear that preparations containing FGF activity were in fact pleiotropic, affecting the growth and function of a wide variety of mesenchymal, endocrine and neural ...
Andrew Baird, Patricia A. Walicke
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The existence of fibroblast growth factors (FGFs) was proposed over 40 years ago to account for the ability of tissue extracts to stimulate fibroblast proliferation. In the 1970s it became clear that preparations containing FGF activity were in fact pleiotropic, affecting the growth and function of a wide variety of mesenchymal, endocrine and neural ...
Andrew Baird, Patricia A. Walicke
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2006
Fibroblast growth factors (FGFs) are a large group of small polypeptide growth factors, some of which play key roles in pulmonary biology. Their molecular sizes vary from 17 to 34 kDa and they share a wide range of amino acid homology with highly conserved gene structures and amino acid sequences.
D. Ornitz, P. Sannes
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Fibroblast growth factors (FGFs) are a large group of small polypeptide growth factors, some of which play key roles in pulmonary biology. Their molecular sizes vary from 17 to 34 kDa and they share a wide range of amino acid homology with highly conserved gene structures and amino acid sequences.
D. Ornitz, P. Sannes
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The International Journal of Biochemistry & Cell Biology, 2000
Fibroblast growth factor-2 (FGF-2) is a member of a large family of proteins that bind heparin and heparan sulfate and modulate the function of a wide range of cell types. FGF-2 stimulates the growth and development of new blood vessels (angiogenesis) that contribute to the pathogenesis of several diseases (i.e.
Renato V. Iozzo, Matthew A. Nugent
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Fibroblast growth factor-2 (FGF-2) is a member of a large family of proteins that bind heparin and heparan sulfate and modulate the function of a wide range of cell types. FGF-2 stimulates the growth and development of new blood vessels (angiogenesis) that contribute to the pathogenesis of several diseases (i.e.
Renato V. Iozzo, Matthew A. Nugent
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Fibroblast Growth Factors and Their Inhibitors
Current Pharmaceutical Design, 2000Fibroblast growth factors (FGFs) are members of a family of polypeptides synthesized by a variety of cell types during the processes of embryonic development and in adult tissues. FGFs have been detected in normal and malignant cells and show a biological profile that includes mitogenic and angiogenic activity with a consequent crucial role in cell ...
MANETTI, FABRIZIO +2 more
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Fibroblast Growth Factors, Fibroblast Growth Factor Receptors, Diseases, and Drugs
Recent Patents on Cardiovascular Drug Discovery, 2006Maintenance of endothelial cells (ECs), the building blocks of the vascular tree, is a presumed function of fibroblast growth factors (FGFs). In particular, the two prototypic members of FGF family, namely FGF1 and FGF2, due to their potent mitogenic and pro-migratory activities, have the ability to induce metabolic and phenotypic changes in ECs that ...
Gregory J Chen, Reza Forough
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Fibroblast growth factors and their receptors
Biochemistry and Cell Biology, 1997Fibroblast growth factors (FGFs) represent a group of polypeptide mitogens eliciting a wide variety of responses depending upon the target cell type. The knowledge of the cell surface receptors mediating the effects of FGFs has recently expanded remarkably. The complexity of the FGF family and the FGF-induced responses is reflected in the diversity and
John A. Smith +2 more
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2003
We have reviewed data showing that FGFs are a family of related factors playing fundamental roles in several biologic processes involving tissue remodeling such as embryonic development, angiogenesis, wound healing, nerve regeneration, and chronic inflammation and cancer.
Ensoli, B +3 more
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We have reviewed data showing that FGFs are a family of related factors playing fundamental roles in several biologic processes involving tissue remodeling such as embryonic development, angiogenesis, wound healing, nerve regeneration, and chronic inflammation and cancer.
Ensoli, B +3 more
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Insulin-like growth factors and their binding proteins: biological actions.
Endocrine reviews, 1995I. Introduction THE insulin-like growth factors were discovered on the basis of their ability to stimulate cartilage sulfation and to replace the “sulfation factor activity” of GH, as determined using an in vivo assay, in an in vitro test system (1). The
John I. Jones, D. Clemmons
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