Results 61 to 70 of about 450,978 (295)

Expression of the FGFR2c mesenchymal splicing variant in human keratinocytes inhibits differentiation and promotes invasion [PDF]

, 2018
The altered isoform switching of the fibroblast growth factor receptor 2 (FGFR2) and aberrant expression of the mesenchymal FGFR2c isoform in epithelial cells is involved in cancer progression.
Anacker, Barbaresi, Barton, Belleudi, Boukamp, Brooks, Candi, Capone, Chaffer, Dotto, Feng, Gaggioli, Getsios, Goetz, Grose, Harmon, Haugsten, Ishiwata, Izar, Jones, Kawase, Matsuda, Oh, Oltean, Peng, Petiot, Pickard, Pickard, Purpura, Raffa, Ramsey, Ranieri, Ranieri, Shamir, Shih, Simpson, Truong, Turner, Warzecha, Warzecha, Yang, Ye, Zhang, Zhao   +43 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

HSV-1 triggers paracrine fibroblast growth factor response from cortical brain cells via immediate-early protein ICP0

Journal of Neuroinflammation, 2019
Background Herpes simplex virus-1 (HSV-1) infections of the central nervous system (CNS) can result in HSV-1 encephalitis (HSE) which is characterized by severe brain damage and long-term disabilities.
Niko Hensel, Verena Raker, Benjamin Förthmann, Nora Tula Detering, Sabrina Kubinski, Anna Buch, Georgios Katzilieris-Petras, Julia Spanier, Viktoria Gudi, Sylvia Wagenknecht, Verena Kopfnagel, Thomas Andreas Werfel, Martin Stangel, Andreas Beineke, Ulrich Kalinke, Søren Riis Paludan, Beate Sodeik, Peter Claus   +17 more
doaj   +1 more source

Purified plasma membranes inhibit polypeptide growth factor-induced DNA synthesis in subconfluent 3T3 cells. [PDF]

, 1984
Plasma membranes derived from NR-6 cells, a variant line of Swiss mouse 3T3 cells that does not have cell surface receptors for epidermal growth factor (EGF), inhibited EGF-induced stimulation of DNA synthesis by 50% in serum-starved, subconfluent 3T3 ...
Fox, CF, Matiuck, NV, Peterson, SW, Vale, RD   +3 more
core  

Comparison of Non-human Primate versus Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Treatment of Myocardial Infarction. [PDF]

, 2018
Non-human primates (NHPs) can serve as a human-like model to study cell therapy using induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). However, whether the efficacy of NHP and human iPSC-CMs is mechanistically similar remains unknown.
Aguirre, Aitor, Chen, Haodong, Chour, Tony, Holmström, Alexandra, Itzhaki, Ilanit, Jain, Mohit, Kim, Youngkyun, Lehmann, Kim, Ndoye, Babacar C, Neofytou, Evgenios, Qin, Xulei, Shukla, Praveen, Wu, Joseph C, Xiao, Dan, Yang, Huaxiao, Zhang, Joe Z, Zhao, Mingtao, Zhao, Xin, Zhuge, Yan, Zimmermann, Wolfram-Hubertus   +19 more
core   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Essential growth factor receptors for fibroblast homeostasis and activation: Fibroblast Growth Factor Receptor (FGFR), Platelet Derived Growth Factor Receptor (PDGFR), and Transforming Growth Factor β Receptor (TGFβR) [version 2; peer review: 2 approved]

F1000Research
Fibroblasts are cells of mesenchymal origin that are found throughout the body. While these cells have several functions, their integral roles include maintaining tissue architecture through the production of key extracellular matrix components, and ...
Matthew B. Buechler, Maye F. Cheng, Faizah S. Abdullah   +2 more
doaj   +1 more source

Effect of cupuassu butter on human skin cells

Data in Brief, 2018
This study investigated the effect of cupuassu butter on the cell number of human skin fibroblasts, as well as the gene expression profiles of certain growth factors in these fibroblasts.
Katsura Sano, Hiroko Kawanobe, Takao Someya   +2 more
doaj   +1 more source

FGF-2 Induces Neuronal Death through Upregulation of System xc- [PDF]

, 2014
The cystine/glutamate antiporter (system xc-) transports cystine into cell in exchange for glutamate. Fibroblast growth factor-2 (FGF-2) upregulates system xc- selectively on astrocytes, which leads to increased cystine uptake, the substrate for ...
Albano, Rebecca, Liu, Xiaoqian, Lobner, Doug   +2 more
core   +1 more source