Results 71 to 80 of about 747,670 (306)
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
The role of A-Type lamins and LAP2a in cellular ageing of human fibroblasts in vitro [PDF]
, 2005 Mutations in LMNA gene have been linked to a number of age-related tissue-specific diseases and premature ageing syndromes termed laminopathies. The finding that A- type lamins affect longevity and maintenance of a number of somatic tissues makes them ...
PekovicÌ, Vanja, Peković, Vanja
core
, 2011 Background: Protease-activated receptors (PARs) can be stimulated by thrombin and other proteases generated by periodontal pathogens. Activation of PARs in gingival fibroblasts (GFs) can modulate wound healing and inflammatory responses in gingival ...
陳朝寶;張美姫;王應然;陳令儀;蔡宜玲;李正喆;賈緖威;鄭景暉 +1 more
core +1 more source
Mechanotransduction in fibroblasts [PDF]
, 2011 Response to mechanical stress is important for tissue homeostasis, tissue architecture and muscle regeneration. All cells of an organism are subject to at least one of three types of mechanical stress: compression, shear stress or tension.
Brosig, Michaela
core +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
, 2009 Previous attempts to delete type II TGFβ receptor (TβRII) in fibroblasts have precluded examination of adult mice due to early mortality. We have selectively deleted TβRII postnatally in differentiated connective tissue fibroblasts using an inducible Cre-
Denton, C.P. +7 more
core +1 more source
microRNA in cellular senescence [PDF]
, 2010 Senescence is recognized as a permanent arrest of cell proliferation triggered by telomere shortening or various stresses. Senescence imposes a barrier to tumorigenesis and contributes to aging.
Sedia, Carla
core +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
, 2023 Fangqing Zhu,1 Sheng Li,2 Qiuping Gu,1 Ningsheng Xie,1 Yinxia Wu3 1Department of Gastroenterology, Ganzhou People’s Hospital, Ganzhou, Jiangxi, 341000, People’s Republic of China; 2Department of Gastroenterology, Yuebei People’s Hospital, Shantou ...
Li S, Zhu F, Xie N, Gu Q, Wu Y
core
Regulation of mucosal inflammation by fibroblasts [PDF]
, 2006 Acute inflammation in the bowel, a response of the immune system to infections or trauma, is probably a frequent but localized event, but when the barrier is repaired and the infection cleared, it is quickly followed by wound healing and resolution ...
Bland, PW +9 more
core +1 more source