Results 71 to 80 of about 3,826 (203)
A Retinoid Antagonist Attenuates Bone Growth Inhibition Caused by Growth Plate Injury in Mice
Journal of Orthopaedic Research, Volume 43, Issue 10, Page 1724-1735, October 2025.ABSTRACT Growth plate injury, which may trigger growth plate fusion or arrest, is a common occurrence in pediatric orthopaedics that can lead to angulation of the limb and limb length discrepancy. Growth plate injuries are currently treated palliatively, with surgical intervention when severe limb length discrepancy or angulation is found during follow‐
Masatake Matsuoka +8 more
wiley +1 more source
Cardiopulmonary and Neurologic Dysfunctions in Fibrodysplasia Ossificans Progressiva
Biomedicines, 2021 Fibrodysplasia Ossificans Progressiva (FOP) is an ultra-rare but debilitating disorder characterized by spontaneous, progressive, and irreversible heterotopic ossifications (HO) at extraskeletal sites.
Fatima Khan +2 more
doaj +1 more source
Heterotopic Ossification: Cellular Basis, Symptoms, and Treatment [PDF]
, 2012 Heterotopic ossification (HO) is the process by which calcified bone develops in soft tissues. Because of the abnormal calcification, complications such as bone deformation, loss of range of motion, and joint immobility adversely affect patients.
Wolfe, Brian
core
Diagnostic Cytopathology, Volume 53, Issue 7, Page E138-E143, July 2025.ABSTRACT Myositis ossificans (MO) is a benign soft tissue lesion, characterized by ectopic ossification due to inappropriate fibroblast differentiation, most commonly affecting skeletal muscles. It often occurs in young adults after muscle trauma, predominantly in male patients and very rarely in children. We describe the case of a previously healthy 3‐
Živa Ledinek +7 more
wiley +1 more source
Nature Communications, 2018 Fibrodysplasia ossificans progressiva is a severe disorder characterized by heterotopic ossification, and is caused by mutations in ACVR1. Here, the authors show that expression of mutant ACVR1 in fibro/adipogenic progenitors recapitulates disease ...
John B. Lees-Shepard +13 more
doaj +1 more source
Post‐COVID‐19 Exacerbation of a Stable Fibrous Dysplasia: A Case Report
Clinical Case Reports, Volume 13, Issue 4, April 2025.ABSTRACT Fibrous dysplasia (FD) is a rare, benign fibro‐osseous lesion characterized by replacement of normal bone with extensive fibrous stroma due to abnormalities in osteoblast differentiation. After puberty and during adulthood, FD lesions usually become quiescent. However, some cases show signs of regrowth and reactivation.
Mohammed Taib Fatih +7 more
wiley +1 more source
Effects of FKBP12 and type II BMP receptors on signal transduction by ALK2 activating mutations associated with genetic disorders [PDF]
, 2018 Various substitution mutations in ALK2, a transmembrane serine/threonine kinase receptor for bone morphogenetic proteins (BMPs), have been identified in patients with genetic disorders such as fibrodysplasia ossificans progressiva (FOP), diffuse ...
Bullock, Alexander +9 more
core +2 more sources
Pediatric Pulmonology, Volume 60, Issue 4, April 2025.ABSTRACT Introduction Childhood interstitial and diffuse lung diseases (chILD) comprise a diverse group of rare disorders. Identifying the underlying cause is crucial for treatment, prognosis, and estimating recurrence risk. The objective of this study was to assess the utilization of genetic testing for subjects enrolled in the United States National ...
Laura A. Voss +23 more
wiley +1 more source
Rheumatology &Autoimmunity, Volume 5, Issue 1, Page 28-36, March 2025.Fibrodysplasia ossificans progressiva, a rare genetic disorder caused by ACVR1 mutations, leads to soft tissue ossification. Recent advancements, including food and drug administration‐approved palovarotene, show promise despite safety concerns. Therapies like tofacitinib and imatinib demonstrate potential, but larger, controlled trials are essential ...
Muhammad Ikrama +6 more
wiley +1 more source
A CASE OF FIBRODYSPLASIA OSSIFICANS PROGRESSIVA WITH PRIMARY AMENORRHEA
Khyber Medical University Journal, 2011 Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant hereditary disorder affecting around one in two million people. It is characterized by heterotopic calcification in muscles, tendons, ligaments, membranes and aponeurosis. It is the
Ayesha zafar +2 more
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