Results 1 to 10 of about 354,159 (381)

Fibronectin Deposition Participates in Extracellular Matrix Assembly and Vascular Morphogenesis. [PDF]

PLoS ONE, 2016
The extracellular matrix (ECM) has been demonstrated to facilitate angiogenesis. In particular, fibronectin has been documented to activate endothelial cells, resulting in their transition from a quiescent state to an active state in which the cells ...
Abigail Hielscher, Kim Ellis, Connie Qiu, Josh Porterfield, Sharon Gerecht   +4 more
doaj   +2 more sources

Circulating Fibronectin Controls Tumor Growth

Neoplasia: An International Journal for Oncology Research, 2013
Fibronectin is ubiquitously expressed in the extracellular matrix, and experimental evidence has shown that it modulates blood vessel formation. The relative contribution of local and circulating fibronectin to blood vessel formation in vivo remains ...
Anja von Au, Matthaeus Vasel, Sabrina Kraft, Carla Sens, Norman Hackl, Alexander Marx, Philipp Stroebel, Jörg Hennenlotter, Tilman Todenhöfer, Arnulf Stenzl, Sarah Schott, Hans-Peter Sinn, Antoinette Wetterwald, Justo Lorenzo Bermejo, Marco G Cecchini, Inaam A Nakchbandi   +15 more
doaj   +2 more sources

Structural insights into integrin α5β1 opening by fibronectin ligand

Science Advances, 2021
Integrin α5β1 structures in resting and active states with ligand fibronectin reveal key interactions for integrin opening. Integrin α5β1 is a major fibronectin receptor critical for cell migration.
S. Schumacher, D. Dedden, R. V. Nunez, K. Matoba, J. Takagi, Christian Biertümpfel, N. Mizuno   +6 more
semanticscholar   +1 more source

Regional fibronectin and collagen fibril co-assembly directs cell proliferation and microtissue morphology. [PDF]

PLoS ONE, 2013
The extracellular matrix protein, fibronectin stimulates cells to self-assemble into three-dimensional multicellular structures by a mechanism that requires the cell-dependent conversion of soluble fibronectin molecules into insoluble fibrils ...
Carlos A Sevilla, Diane Dalecki, Denise C Hocking   +2 more
doaj   +1 more source

Plasma Fibronectin as a Novel Predictor of Coronary Heart Disease: A Retrospective Study

Journal of Cardiovascular Development and Disease, 2023
Although fibronectin has been associated with the pathogenesis of atherosclerosis, little is currently known about the relationship between plasma fibronectin and coronary heart disease (CHD).
Longyun Peng, Haiwei Deng, Jie Li, Guihua Lu, Yuan-Sheng Zhai   +4 more
doaj   +1 more source

Full-Length Fibronectin Drives Fibroblast Accumulation at the Surface of Collagen Microtissues during Cell-Induced Tissue Morphogenesis. [PDF]

PLoS ONE, 2016
Generating and maintaining gradients of cell density and extracellular matrix (ECM) components is a prerequisite for the development of functionality of healthy tissue. Therefore, gaining insights into the drivers of spatial organization of cells and the
Jasper Foolen, Jau-Ye Shiu, Maria Mitsi, Yang Zhang, Christopher S Chen, Viola Vogel   +5 more
doaj   +1 more source

JMJD6 Dysfunction Due to Iron Deficiency in Preeclampsia Disrupts Fibronectin Homeostasis Resulting in Diminished Trophoblast Migration

Frontiers in Cell and Developmental Biology, 2021
The mechanisms contributing to excessive fibronectin in preeclampsia, a pregnancy-related disorder, remain unknown. Herein, we investigated the role of JMJD6, an O2- and Fe2+-dependent enzyme, in mediating placental fibronectin processing and function ...
Sruthi Alahari, Sruthi Alahari, Abby Farrell, Abby Farrell, Leonardo Ermini, Chanho Park, Julien Sallais, Julien Sallais, Sarah Roberts, Taylor Gillmore, Taylor Gillmore, Michael Litvack, Martin Post, Martin Post, Martin Post, Isabella Caniggia, Isabella Caniggia, Isabella Caniggia, Isabella Caniggia   +18 more
doaj   +1 more source

Conformational changes of exogenous deposited fibronectin on decellularized aortic conduits after implantation

Vietnam Journal of Science, Technology and Engineering, 2022
Fibronectin is an abundant and ubiquitous extracellular matrix component that regulates a wide range of cell functions by directly interacting with cell surface integrin receptors.
Khon Huynh
doaj   +1 more source

Fibronectin: structure, functions, clinical significance (review)

Атеротромбоз, 2022
Plasma fibronectin is a high molecular weight adhesive glycoprotein. There are two types of fibronectin: plasma (soluble) and cellular derived (insoluble).
S. A. Vasiliev, L. A. Gorgidze, E. E. Efremov, G. Yu. Belinin, T. N. Moiseeva, L. S. Al-Radi, M. A. Sokolova, G. T. Guria, N. I. Zozulya, A. V. Kokhno   +9 more
doaj   +1 more source

Fibronectin promotes tumor angiogenesis and progression of non-small-cell lung cancer by elevating WISP3 expression via FAK/MAPK/ HIF-1α axis and activating wnt signaling pathway

Experimental Hematology & Oncology, 2023
Background Fibronectin, an extracellular matrix protein, has been reported to be associated with heterogeneous cancer stemness, angiogenesis and progression in multiple cancer types.
Fei Zhou, Jianguo Sun, Lingyun Ye, Tao Jiang, Wei Li, Chunxia Su, Shengxiang Ren, Fengying Wu, Caicun Zhou, Guanghui Gao   +9 more
doaj   +1 more source