Results 181 to 190 of about 201,822 (256)

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

MITF-Driven melanoma plasticity as a core mechanism of therapy resistance: integrating microenvironmental signaling, mechanotransduction, and metabolic reprogramming. [PDF]

Cell Cycle
Kisielewska M, Suwała S, Drąg-Zalesińska M, Rembiałkowska N.   +3 more
europepmc   +1 more source

Black phosphorus‐based photothermal disruption of cancer‐associated fibroblast barriers and tumor‐associated macrophage targeting to enhance anti‐PD‐L1 immunotherapy in triple‐negative breast cancer

Interdisciplinary Medicine, EarlyView.
MBB modulates the TNBC tumor microenvironment by targeting TAM/CXCL1 and facilitates anti‐PD‐L1 therapy by disrupting CAF barriers via its photothermal effect. This combined strategy subsequently enhances the efficacy of PD‐L1 mAb and suppresses TNBC progression, metastasis, and recurrence.
Bo Pan, Shicui Hong, Xinyue Wang, Yanghang Li, Cai Wang, Yaxiao Liu, Ying Chen, Chen Fang, Yifeng Zheng, Shengqi Wang, Juping Zhang, Neng Wang, Zhiyu Wang   +12 more
wiley   +1 more source

Microglia in diffuse midline glioma contribute to extracellular matrix remodelling and cancer cell invasion. [PDF]

Cell Death Dis
Keane L, Škandík M, Posada-Pérez M, Bose R, Desito J, van der Linde E, Engskog-Vlachos P, Ceccatelli S, Green AL, Joseph B.   +9 more
europepmc   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Developing a protocol to counteract spontaneous in vitro activation of intestinal fibroblasts using design of experiments. [PDF]

NPJ Biomed Innov
Mohammadalizadeh Z, Sudi S, Basto Moreno DA, Bauer Estrada K, Almonte M, Fogg KC, Porras AM.   +6 more
europepmc   +1 more source

Current strategies to enhance the target efficiency of advanced multifunctional ultrasound contrast agents in ischemic diseases

Interdisciplinary Medicine, EarlyView.
The graphical abstract outlines a novel multifunctional ultrasound contrast agent for the diagnosis and treatment of ischemic diseases, along with innovative strategies to enhance its targeting efficiency. Abstract Ischemic diseases, such as myocardial infarction, stroke, and peripheral ischemia, are leading causes of death and disability worldwide ...
Yangyang Zhou, Jing Lin, Yu Chen, Jiaqi Zhao   +3 more
wiley   +1 more source

Basigin (CD147) and calpain 4 (CapnS1) are partners in the generation of traction force but not in mechanosensing. [PDF]

J Biol Chem
DeTone J, Kozole S, Stewart M, Hao B, Beningo KA.   +4 more
europepmc   +1 more source

Low‐Level Human Epididymis Protein 4 in Seminal Plasma Is an Independent Risk Factor for Poor Semen Liquefaction: A Case Control Study

Journal of Clinical Laboratory Analysis, EarlyView.
Our work identifies a novel and significant association between low seminal levels of Human Epididymis Protein 4 (HE4) and the clinical condition of poor semen liquefaction, a common cause of male infertility. The findings are statistically robust, clinically relevant, and provide a foundational basis for future research into the mechanism by which HE4
Feifei Wang, Jiangnan Wu, Shijie Gao, Zhuohan Zheng, Zhiheng Wang, Jing Gao   +5 more
wiley   +1 more source

Targeting CD30L Alleviates Airway Remodeling via JNK/p38 MAPK Pathway in OVA-Induced Asthmatic Mice. [PDF]

Allergy Asthma Immunol Res
Xu C, Liu X, Zeng R, Zhang J, Pan Y, Qiao C, Wang P, Shi S, Wang Y, Liu X, Qi Q, Gao M, Zhi L, Dong X, Fei J, Dong L.   +15 more
europepmc   +1 more source