Results 231 to 240 of about 323,080 (292)

ACLY‐Driven Metabolic Reprogramming Promotes Histone Acetylation and Inflammation‐Associated Fibrosis in Chronic Kidney Disease

Advanced Science, EarlyView.
This study reveals a citrate–ACLY–H3K27ac metabolic–epigenetic axis driving inflammatory gene activation and kidney fibrosis, highlighting ACLY inhibition as a potential therapeutic strategy for chronic kidney disease (CKD). ABSTRACT The mechanisms by which metabolic stress drives epigenetic dysregulation and fibrosis in chronic kidney disease (CKD ...
Chunxiu Du, Dhanunjay Mukhi, Lingzhi Li, Chenyu Li, Siyu Pan, Bernhard Dumoulin, Eunji Ha, Lakshmi P Kolligundla, Yanjuan Hou, Jonathan Levinsohn, Chaelin Kang, Konstantin Adrian Klötzer, Junnan Wu, Samer Mohandes, Kathryn E Wellen, Katalin Susztak   +15 more
wiley   +1 more source

Exercise training ameliorates myocardial dysfunction through fibronectin-mediated mechanotransduction in a swine model of ischemic heart disease. [PDF]

Am J Physiol Heart Circ Physiol
Lee Y, Wu X, Narayanan A, Chakraborty S, Heaps CL, Muthuchamy M.   +5 more
europepmc   +1 more source

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

Correction to "Exosomal MicroRNAs Derived from Human Amniotic Epithelial Cells Accelerate Wound Healing by Promoting the Proliferation and Migration of Fibroblasts". [PDF]

Stem Cells Int
europepmc   +1 more source

Surface CD81 supports leukemia stem cell function and reveals a therapeutic vulnerability in acute myeloid leukemia. [PDF]

Signal Transduct Target Ther
Gonzales F, Peyrouze P, Laurent D, Boyer T, Boukrout N, Couturier C, Houdiard S, Lisi V, Barthélémy A, Sevrin F, Plesa A, Bongiovanni A, Pottier N, Preudhomme C, Lavallée VP, Geles K, Duployez N, Berthon C, Roumier C, Cheok M.   +19 more
europepmc   +1 more source

Reprogramming Antitumor Immunity: NK Cell Strategies to Navigate the Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs, Pranay Nath, Alice Chen, Rizwan Romee, Andreia Maia   +4 more
wiley   +1 more source

BMAL1 attenuates myocardial infarction-induced fibrosis via suppressing p-SMAD3/SMAD3 in TGF-β1 pathway. [PDF]

Biochem Biophys Rep
Zhang D, Wang H, Gu Z, Zhang L, Hu Z, Wang Y.   +5 more
europepmc   +1 more source

Glycosylated fibronectin: a maternal serum biomarker for diagnosing gestational diabetes mellitus. [PDF]

Anat Cell Biol
Prasad RHN, Somanna P, Shetty VH, Ningappa RK, Krishnappa M.   +4 more
europepmc   +1 more source

Characterizing histological fatty accumulation, muscle atrophy, and fibrosis in relation to re-tear and revision after primary rotator cuff repair: a mean 3-year follow-up study. [PDF]

JSES Rev Rep Tech
Ruderman LV, Ibarra J, Rueckert H, Leinroth AP, Lorentz S, Cook C, Klifto C, Hilton MJ, Anakwenze OA.   +8 more
europepmc   +1 more source