Results 21 to 30 of about 196,664 (232)

Fibronectin protects from excessive liver fibrosis by modulating the availability of and responsiveness of stellate cells to active TGF-β. [PDF]

PLoS ONE, 2011
Fibrotic tissue in the liver is mainly composed of collagen. Fibronectin, which is also present in fibrotic matrices, is required for collagen matrix assembly in vitro. It also modulates the amount of growth factors and their release from the matrix.
Nina Kawelke, Matthaeus Vasel, Carla Sens, Anja von Au, Steven Dooley, Inaam A Nakchbandi   +5 more
doaj   +1 more source

Engineered Biomimetic Fibrillar Fibronectin Matrices Regulate Cell Adhesion Initiation, Migration, and Proliferation via α5β1 Integrin and Syndecan‐4 Crosstalk

Advanced Science, 2023
Cells regulate adhesion to the fibrillar extracellular matrix (ECM) of which fibronectin is an essential component. However, most studies characterize cell adhesion to globular fibronectin substrates at time scales long after cells polarize and migrate ...
Seungkuk Ahn, Upnishad Sharma, Krishna Chaitanya Kasuba, Nico Strohmeyer, Daniel J. Müller   +4 more
doaj   +1 more source

Candida albicans Adhesion Measured by Optical Nanomotion Detection

Fermentation, 2023
Cellular adhesion plays an important role in numerous fundamental physiological and pathological processes. Its measurement is relatively complex, requires sophisticated equipment, and, in most cases, cannot be carried out without breaking the links ...
Maria I. Villalba, Salomé LeibundGut-Landmann, Marie-Elisabeth Bougnoux, Christophe d’Enfert, Ronnie G. Willaert, Sandor Kasas   +5 more
doaj   +1 more source

Fibronectin aggregates promote features of a classically and alternatively activated phenotype in macrophages

Journal of Neuroinflammation, 2018
Background Means to promote endogenous remyelination in multiple sclerosis (MS) benefit from insights into the role of inhibitory molecules that preclude remyelination.
Arend H. Sikkema, Josephine M. J. Stoffels, Peng Wang, Frederike J. Basedow, Robbert Bulsink, Jeffrey J. Bajramovic, Wia Baron   +6 more
doaj   +1 more source

Circulating Fibronectin Controls Tumor Growth

Neoplasia: An International Journal for Oncology Research, 2013
Fibronectin is ubiquitously expressed in the extracellular matrix, and experimental evidence has shown that it modulates blood vessel formation. The relative contribution of local and circulating fibronectin to blood vessel formation in vivo remains ...
Anja von Au, Matthaeus Vasel, Sabrina Kraft, Carla Sens, Norman Hackl, Alexander Marx, Philipp Stroebel, Jörg Hennenlotter, Tilman Todenhöfer, Arnulf Stenzl, Sarah Schott, Hans-Peter Sinn, Antoinette Wetterwald, Justo Lorenzo Bermejo, Marco G Cecchini, Inaam A Nakchbandi   +15 more
doaj   +1 more source

Matrix Gla Protein Binds to Fibronectin and Enhances Cell Attachment and Spreading on Fibronectin

International Journal of Cell Biology, 2014
Background. Matrix Gla protein (MGP) is a vitamin K-dependent, extracellular matrix protein. MGP is a calcification inhibitor of arteries and cartilage.
Satoru Ken Nishimoto, Miyako Nishimoto
doaj   +1 more source

Glycoproteomic Analysis Reveals Aberrant Expression of Complement C9 and Fibronectin in the Plasma of Patients with Colorectal Cancer

Proteomes, 2020
Colorectal cancer (CRC) is a major cause of cancer mortality. Currently used CRC biomarkers provide insufficient sensitivity and specificity; therefore, novel biomarkers are needed to improve the CRC detection.
Juthamard Chantaraamporn, Voraratt Champattanachai, Amnart Khongmanee, Chris Verathamjamras, Naiyarat Prasongsook, Kanokwan Mingkwan, Virat Luevisadpibul, Somchai Chutipongtanate, Jisnuson Svasti   +8 more
doaj   +1 more source

The versatile roles of ADAM8 in cancer cell migration, mechanics, and extracellular matrix remodeling

Frontiers in Cell and Developmental Biology, 2023
The posttranslational proteolytic cleavage is a unique and irreversible process that governs the function and half-life of numerous proteins. Thereby the role of the family of A disintegrin and metalloproteases (ADAMs) plays a leading part.
Claudia Tanja Mierke
doaj   +1 more source

Display of cell surface sites for fibronectin assembly is modulated by cell adherence to (1)F3 and C-terminal modules of fibronectin.

PLoS ONE, 2009
BackgroundFibronectin-null cells assemble soluble fibronectin shortly after adherence to a substrate coated with intact fibronectin but not when adherent to the cell-binding domain of fibronectin (modules (7)F3-(10)F3).
Jielin Xu, Eunnyung Bae, Qinghong Zhang, Douglas S Annis, Harold P Erickson, Deane F Mosher   +5 more
doaj   +1 more source

Interleukin-4 and interleukin-13 induce fibronectin production by human lung fibroblasts

Allergology International, 2001
Background: Interleukin (IL)-4 and IL-13, which play a role in the production of allergic inflammation, can activate fibroblasts to elicit a variety of cellular functions.
Tatsuya Machino, Shu Hashimoto, Yasuhiro Gon, Kosei Kujime, Shuichiro Maruoka, Takashi Horie   +5 more
doaj   +1 more source