Results 41 to 50 of about 11,226 (256)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

In Vitro Impact of Triatomine Salivary Glands Extracts Introduced to Endothelial Cells [PDF]

, 2018
Chagas Disease (AKA Trypanosomiasis) is caused by biting/feeding behavior from the arthropod vector Triatoma (subfamily of Reduviidae family), that house the endoparasite Trypanosoma cruzi, which can then be passed to human and mammalian hosts (Schmidt ...
Abernathy, Roger, Londono-Renteria, Berline, Montenegro-Cadena, Lidia   +2 more
core  

Adhiron: a stable and versatile peptide display scaffold for molecular recognition applications [PDF]

, 2014
We have designed a novel non-antibody scaffold protein, termed Adhiron, based on a phytocystatin consensus sequence. The Adhiron scaffold shows high thermal stability (Tm ca. 101°C), and is expressed well in Escherichia coli. We have determined the X-ray
Afonine, Anna A. S. Tang, Binz, Bode, Carter, Christian Tiede, Colwill, Corpet, Darren C. Tomlinson, David J. Harrison, Emsley, Evans, Forrer, Gebauer, Gilbreth, Grebien, Hoogenboom, Horton, Irene, Jacobs, Joanne E. Nettleship, Kabsch, Kerscher, Knappik, Kohl, Koide, Komor, Kondo, Krumpe, Lee, Lehmann, Li, Main, McCoy, Michael J. McPherson, Mosavi, Murshudov, Nagata, Nixon, Nord, Parizek, Raymond J. Owens, Reichert, Robin L. Owen, Sarah E. Deacon, Schellenberger, Schlehuber, Schweizer, Skerra, Song, Song, Steiner, Steipe, Stubbs, Suja E. George, Sun, Theurillat, Upasana Mandal, Walter, Wetzel, Wojcik, Wurch   +61 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Detection of Fibronectin-Binding Proteins in Clostridium perfringens. [PDF]

, 2006
Clostridium perfringens is an anaerobic spore-forming pathogen of humans and animals. C. perfringens type A strains, 13, CPN50, and NCTC8237, isolated from human gas gangrene, bound specifically to human fi bronectin (Fn).
Hitsumoto, Yasuo, Katayama, Seiichi, Nozu, Nanami, Yokoyama, Masako   +3 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Triglycerides Predict Plasma Fibronectin in Children with Type I Diabetes Mellitus Rather than Diabetes

Acta Medica, 2002
Fibronectins are adhesive proteins considered as markers of endothelial activation. Plasma fibronectin levels in diabetes mellitus (DM) have been found to be associated with atherosclerotic risk factors.
Ayşe Binnur Erbağcı, Mehmet Tarakçıoğlu, Ahmet Erbağcı, Mehmet Gözübüyük, Necat Yılmaz, Rukiye Deveci, Ramazan Kocabaş   +6 more
doaj   +1 more source

Fibronectin and Fibronectin Receptors in Lung Development

Experimental Lung Research, 1997
Fibronectin (FN) is a cell adhesive extracellular matrix protein highly expressed in developing lungs. Although the role of FN in lung development remains to be elucidated, several observations suggest that it plays important roles in many developmental processes. In vitro, FN can affect the migration, proliferation, differentiation, and even apoptosis
openaire   +2 more sources

Matrix metalloproteinase 9 and cellular fibronectin plasma concentrations are predictors of the composite endpoint of length of stay and death in the intensive care unit after severe traumatic brain injury [PDF]

, 2012
BACKGROUND: The relationship between severe traumatic brain injury (TBI) and blood levels of matrix metalloproteinase-9 (MMP-9) or cellular fibronectin (c-Fn) has never been reported. In this study, we aimed to assess whether plasma concentrations of MMP-
Bernhard Walder, Jean-Charles Sanchez, Jean-Christophe Copin, Karl Schaller, Marie My Lien Rebetez, Natacha Turck, Xavier Robin, Yvan Gasche   +7 more
core   +2 more sources