Expression and function of alpha(v)beta(3) and alpha(v)beta(5) integrins in the developing pancreas: roles in the adhesion and migration of putative endocrine progenitor cells. [PDF]
, 2000 Cell-cell and cell-matrix interactions play a critical role in tissue morphogenesis and in homeostasis of adult tissues. The integrin family of adhesion receptors regulates cellular interactions with the extracellular matrix, which provides three ...
Alpert +67 more
core +1 more source
Using molecular mechanics to predict bulk material properties of fibronectin fibers [PDF]
, 2012 The structural proteins of the extracellular matrix (ECM) form fibers with finely tuned mechanical properties matched to the time scales of cell traction forces.
Bradshaw, Mark J. +3 more
core +2 more sources
Frontiers in Bioengineering and Biotechnology, 2015 During development, bone morphogenetic proteins (BMPs) exert important functions in several tissues by regulating signaling for cell differentiation and migration. In vivo the extracellular matrix (ECM) not only provides a support for adherent cells, but
Kristin eHauff +11 more
doaj +1 more source
Neural crest cell-autonomous roles of fibronectin in cardiovascular development. [PDF]
, 2015 The chemical and mechanical properties of extracellular matrices (ECMs) modulate diverse aspects of cellular fates; however, how regional heterogeneity in ECM composition regulates developmental programs is not well understood.
Astrof, Sophie, Wang, Xia
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Interaction between extracellular matrix molecules and microbial pathogens: evidence for the missing link in autoimmunity with rheumatoid arthritis as a disease model. [PDF]
, 2014 Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation followed by tissue rebuilding or fibrosis. A failure by the body to regulate inflammation effectively is one of the hallmarks of RA.
Bella +31 more
core +3 more sources
Adhiron: a stable and versatile peptide display scaffold for molecular recognition applications [PDF]
, 2014 We have designed a novel non-antibody scaffold protein, termed Adhiron, based on a phytocystatin consensus sequence. The Adhiron scaffold shows high thermal stability (Tm ca. 101°C), and is expressed well in Escherichia coli. We have determined the X-ray
Afonine +61 more
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CD9 controls integrin α5β1-mediated cell adhesion by modulating its association with the metalloproteinase ADAM17 [PDF]
, 2018 Integrin α5β1 is a crucial adhesion molecule that mediates the adherence of many cell types to the extracellular matrix through recognition of its classic ligand fibronectin as well as to other cells through binding to an alternative counter-receptor ...
Cabañas, Carlos +10 more
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
In Vitro Impact of Triatomine Salivary Glands Extracts Introduced to Endothelial Cells [PDF]
, 2018 Chagas Disease (AKA Trypanosomiasis) is caused by biting/feeding behavior from the arthropod vector Triatoma (subfamily of Reduviidae family), that house the endoparasite Trypanosoma cruzi, which can then be passed to human and mammalian hosts (Schmidt ...
Abernathy, Roger +2 more
core
Endothelium-derived fibronectin regulates neonatal vascular morphogenesis in an autocrine fashion [PDF]
, 2017 Fibronectin containing alternatively spliced EIIIA and EIIIB domains is largely absent from mature quiescent vessels in adults, but is highly expressed around blood vessels during developmental and pathological angiogenesis.
Badu-Nkansah, Kwabena +2 more
core +2 more sources