Results 251 to 260 of about 1,163,030 (369)

YC‐4‐3, a Novel Glycogen Synthase Kinase 3β Inhibitor, Alleviates the Endoplasmic Reticulum Stress of Macrophages in Primary Immune Thrombocytopenia

Advanced Science, EarlyView.
A patented GSK‐3β inhibitor (GSK‐3βi), new benzothiazepinone compounds (BTZs), YC‐4‐3, can modulate the inflammatory status of macrophages in primary immune thrombocytopenia (ITP), and improve the thrombocytopenia in murine ITP models by directly interacting with endoplasmic reticulum (ER) stress response.
Pengcheng Xu, Lili Ji, Yanxia Zhan, Yang Ou, Xia Shao, Xibing Zhuang, Fanli Hua, Feng Li, Hao Chen, Yong Chu, Yunfeng Cheng   +10 more
wiley   +1 more source

Cardiac Fibrosis in the Multi-Omics Era: Implications for Heart Failure. [PDF]

Circ Res
Ghazal R, Wang M, Liu D, Tschumperlin DJ, Pereira NL.   +4 more
europepmc   +1 more source

Anesthetic Experience in Children with Cystic Fibrosis of the Pancreas [PDF]

, 1964
Ernest Salanitre, D. H. Klonymus, Herbert Rackow   +2 more
openalex   +1 more source

Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications

Advanced Science, EarlyView.
HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Zhiyi Wang, Xiaofan Zhu, Zhenzhou Huang, Kaidi Ren, Jie Ran, Yang Yang   +5 more
wiley   +1 more source

REST contributes to renal fibrosis through inducing mitochondrial energy metabolism imbalance in tubular epithelial cells. [PDF]

Cell Commun Signal
Yang Y, Gong S, Zhou C, Xin W, Qin S, Yao M, Lan Q, Liao W, Zhao J, Huang Y.   +9 more
europepmc   +1 more source

Diffuse fibrosing alveolitis (diffuse interstitial fibrosis of the lungs): Correlation of histology at biopsy with prognosis

, 1967
J. G. Scadding, K. F. W. Hinson
openalex   +1 more source

Rapid method for the detection of cystic fibrosis of the pancreas in children. [PDF]

, 1967
B. A. Saggers, D. Lawson, J. Stern, A. C. Edgson   +3 more
openalex   +1 more source

Machine Learning‐Enabled Drug‐Induced Toxicity Prediction

Advanced Science, EarlyView.
Unexpected toxicity accounts for 30% of drug development failures. This review highlights ML innovations in predicting drug‐induced toxicity, emphasizing comparative analyses, interpretable algorithms, and multi‐source data integration. It categorizes toxicity types, summarizes ML models, and organizes key databases, offering strategies to address ...
Changsen Bai, Lianlian Wu, Ruijiang Li, Yang Cao, Song He, Xiaochen Bo   +5 more
wiley   +1 more source

Hesperidin alleviates pulmonary fibrosis by regulating EI24-mediated autophagy. [PDF]

Future Sci OA
Zhang Y, Ma W, Wan F.
europepmc   +1 more source

COMPARISON OF SOME PROPERTIES OF PSEUDOMONAS AERUGINOSA ISOLATED FROM INFECTIONS IN PERSONS WITH AND WITHOUT CYSTIC FIBROSIS

, 1964
Robert G. Doggett, Gunyon M. Harrison, Everett S. Wallis   +2 more
openalex   +1 more source