Results 61 to 70 of about 607,838 (295)

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis

American Journal of Respiratory and Critical Care Medicine, 2019
Rationale: The contributions of diverse cell populations in the human lung to pulmonary fibrosis pathogenesis are poorly understood. Single-cell RNA sequencing can reveal changes within individual cell populations during pulmonary fibrosis that are ...
P. Reyfman, J. Walter, N. Joshi, K. R. Anekalla, Alexandra McQuattie-Pimentel, Stephen Chiu, Ramiro Fernandez, Mahzad Akbarpour, Ching‐I Chen, Z. Ren, R. Verma, H. Abdala-Valencia, Kiwon Nam, Monica Chi, SeungHye Han, Francisco J. Gonzalez-Gonzalez, S. Soberanes, Satoshi Watanabe, Kinola J. N. Williams, A. S. Flozak, T. Nicholson, Vince K. Morgan, D. Winter, M. Hinchcliff, C. Hrusch, R. Guzy, C. Bonham, A. Sperling, R. Bag, R. Hamanaka, G. Mutlu, A. Yeldandi, Stacy A. Marshall, A. Shilatifard, L. Amaral, H. Perlman, J. Sznajder, A. Argento, C. Gillespie, J. Dematte, M. Jain, Benjamin D. Singer, K. Ridge, A. Lam, A. Bharat, S. Bhorade, C. Gottardi, G. S. Budinger, A. Misharin   +48 more
semanticscholar   +1 more source

Mechanisms of Fibrosis Development in NASH.

Gastroenterology, 2020
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease world-wide, affecting 20-25% of the adult population. In 25% of patients, NAFLD progresses to non-alcoholic steatohepatitis (NASH), which increases the risk for the development
R. Schwabe, I. Tabas, U. Pajvani
semanticscholar   +1 more source

Immunoregulatory mechanisms of the arachidonic acid pathway in cancer

FEBS Letters, EarlyView.
The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine, Matteo Mucci, Antonio Recchiuti, Domenico Mattoscio   +3 more
wiley   +1 more source

Elexacaftor/Tezacaftor/Ivacaftor Efficacy in a Cohort of Italian Patients with CFTR Rare Mutations

International Journal of Translational Medicine
Background: Cystic Fibrosis is an inherited disorder caused by mutations in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene, encoding a chloride and bicarbonate channel widely expressed in epithelia.
Francesca Lucca, Sonia Volpi, Mirco Ros, Benedetta Fabrizzi, Ilaria Meneghelli, Marica Bordicchia, Francesca Buniotto, Alessia Lancini, Cecilia Brignole, Francesca Pauro, Valentino Bezzerri, Marco Cipolli   +11 more
doaj   +1 more source

How are the ancient cystic fibrosis patients? Cystic fibrosis diagnosed over 60 years-old

Respiratory Medicine Case Reports, 2017
Background and aims: To specify the prevalence of patients diagnosed with CF at age of ≥60 year-old and to analyze their characteristics. Patients and methods: Observational study of CF patients which were diagnosed at age ≥60 year-old.
C. Prados, M. Lerín, J.J. Cabanillas, L. Gómez-Carrera, R. Álvarez-Sala, M.T. Martinez, L. Máiz, R.M. Girón, A. Solé, M. Martínez, S. Quirós   +10 more
doaj   +1 more source

The NAFLD fibrosis score: A noninvasive system that identifies liver fibrosis in patients with NAFLD

Hepatology, 2007
Patients with nonalcoholic fatty liver disease (NAFLD) and advanced liver fibrosis are at the highest risk for progressing to end‐stage liver disease. We constructed and validated a scoring system consisting of routinely measured and readily available ...
P. Angulo, J. Hui, G. Marchesini, E. Bugianesi, J. George, G. Farrell, F. Enders, S. Saksena, A. Burt, J. Bida, K. Lindor, S. Sanderson, M. Lenzi, L. Adams, J. Kench, T. Therneau, C. Day   +16 more
semanticscholar   +1 more source

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source

Nos2 deficiency enhances carbon tetrachloride-induced liver injury in aged mice [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): As a multifunctional molecule, NO has different effects on liver injury. The present work aimed to investigate the effects of Nos2 knockout (KO) on acute liver injury in aged mice treated with carbon tetrachloride (CCl4).
Deming Li, Yaping Song, Yahao Wang, Yuedong Guo, Zhaoke Zhang, Ganggang Yang, Gaiping Wang, Cunshuan Xu   +7 more
doaj   +1 more source

Stroma gene signature predicts responsiveness to chemotherapy in pancreatic ductal adenocarcinoma patient‐derived xenograft models

Molecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma patient‐derived xenografts (PDAC‐PDXs) engrafted orthotopically in the pancreas of immunodeficient mice retain the main genetic and histopathological characteristics of the original human tumors. A 294 stroma gene signature differentiates between PDAC‐PDXs that are responsive to gemcitabine plus nab‐paclitaxel versus ...
Alessia Anastasia, Laura Formenti, Paola Ostano, Lucia Minoli, Andrea Resovi, Lavinia Morosi, Claudia Fioravanti, Edoardo Micotti, Cristina Matteo, Eugenio Scanziani, Giovanna Chiorino, Raffaella Giavazzi, Carmen Ghilardi, Dorina Belotti   +13 more
wiley   +1 more source