Results 61 to 70 of about 1,754,298 (385)

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Novel Omega-3 Fatty Acid Epoxygenase Metabolite Reduces Kidney Fibrosis. [PDF]

, 2016
Cytochrome P450 (CYP) monooxygenases epoxidize the omega-3 polyunsaturated fatty acid (PUFA) docosahexaenoic acid into novel epoxydocosapentaenoic acids (EDPs) that have multiple biological actions.
Hammock, Bruce D, Hye Khan, Md Abdul, Imig, John D, Lee, Kin Sing Stephen, Levick, Scott P, Sharma, Amit   +5 more
core   +3 more sources

Association Between Fibrosis Stage and Outcomes of Patients with Non-Alcoholic Fatty Liver Disease: a Systematic Review and Meta-Analysis.

Gastroenterology, 2020
BACKGROUND & AIMS Biopsy-confirmed liver fibrosis is a prognostic factor for patients with non-alcoholic fatty liver disease (NAFLD). We performed a systematic review to quantify the prognostic value of fibrosis stage in patients with NAFLD and the ...
R. Taylor, R. J. Taylor, S. Bayliss, H. Hagström, P. Nasr, J. Schattenberg, M. Ishigami, H. Toyoda, V. Wai‐Sun Wong, N. Peleg, A. Shlomai, G. Sebastiani, Yuya Seko, N. Bhala, Z. Younossi, Q. Anstee, S. McPherson, P. Newsome   +17 more
semanticscholar   +1 more source

Validating the Data Completeness and Accuracy of the Canadian Cystic Fibrosis Registry

Canadian Respiratory Journal
Conclusion: Our validation of the CCFR demonstrated high accuracy for clinical and demographic variables used in clinical research.
Ranjani Somayaji, Stephanie Y. Cheng, Noma Abdulrahem, Sanja Stanojevic, Paul Eckford, Bradley S. Quon, Elizabeth Cromwell, Albert Faro, Christopher H. Goss, Anne L. Stephenson   +9 more
doaj   +1 more source

Can early Burkholderia cepacia complex infection in cystic fibrosis be eradicated with antibiotic therapy?

Frontiers in Cellular and Infection Microbiology, 2011
IntroductionOrganisms of the Burkholderia cepacia complex (BCC) are important pathogens in cystic fibrosis (CF). The majority of those who acquire BCC develop chronic infection but it can also result in rapid decline in a significant minority.
Alex eHorsley, Alex eHorsley, Kevin eWebb, Kevin eWebb, Rowland eBright-Thomas, John eGovan, Andrew M Jones, Andrew M Jones   +7 more
doaj   +1 more source

A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion

Nature Communications, 2021
Premature termination codons can cause early translation termination and lead to disease. Here the authors perform a screen to identify compounds with readthrough activity and show that these reduce eRF1 levels to suppress premature termination ...
Jyoti Sharma, Ming Du, Eric Wong, Venkateshwar Mutyam, Yao Li, Jianguo Chen, Jamie Wangen, Kari Thrasher, Lianwu Fu, Ning Peng, Liping Tang, Kaimao Liu, Bini Mathew, Robert J. Bostwick, Corinne E. Augelli-Szafran, Hermann Bihler, Feng Liang, Jerome Mahiou, Josef Saltz, Andras Rab, Jeong Hong, Eric J. Sorscher, Eric M. Mendenhall, Candice J. Coppola, Kim M. Keeling, Rachel Green, Martin Mense, Mark J. Suto, Steven M. Rowe, David M. Bedwell   +29 more
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Coagulation and anticoagulation in idiopathic pulmonary fibrosis [PDF]

, 2015
Idiopathic pulmonary fibrosis (IPF) is an incurable, progressive interstitial lung disease with a prognosis that is worse than that of many cancers. Epidemiological studies have demonstrated a link between IPF and thrombotic vascular events.
Crooks, Michael G., Hart, Simon P.
core   +3 more sources

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis

American Journal of Respiratory and Critical Care Medicine, 2019
Rationale: The contributions of diverse cell populations in the human lung to pulmonary fibrosis pathogenesis are poorly understood. Single-cell RNA sequencing can reveal changes within individual cell populations during pulmonary fibrosis that are ...
P. Reyfman, J. Walter, N. Joshi, K. R. Anekalla, Alexandra McQuattie-Pimentel, Stephen Chiu, Ramiro Fernandez, Mahzad Akbarpour, Ching‐I Chen, Z. Ren, R. Verma, H. Abdala-Valencia, Kiwon Nam, Monica Chi, SeungHye Han, Francisco J. Gonzalez-Gonzalez, S. Soberanes, Satoshi Watanabe, Kinola J. N. Williams, A. S. Flozak, T. Nicholson, Vince K. Morgan, D. Winter, M. Hinchcliff, C. Hrusch, R. Guzy, C. Bonham, A. Sperling, R. Bag, R. Hamanaka, G. Mutlu, A. Yeldandi, Stacy A. Marshall, A. Shilatifard, L. Amaral, H. Perlman, J. Sznajder, A. Argento, C. Gillespie, J. Dematte, M. Jain, Benjamin D. Singer, K. Ridge, A. Lam, A. Bharat, S. Bhorade, C. Gottardi, G. S. Budinger, A. Misharin   +48 more
semanticscholar   +1 more source

Decoding myofibroblast origins in human kidney fibrosis

Nature, 2020
Kidney fibrosis is the hallmark of chronic kidney disease progression; however, at present no antifibrotic therapies exist 1 – 3 . The origin, functional heterogeneity and regulation of scar-forming cells that occur during human kidney fibrosis remain ...
C. Kuppe, Mahmoud M. Ibrahim, J. Kranz, Xiaoting Zhang, S. Ziegler, J. Perales-Patón, J. Jansen, Katharina C. Reimer, James R. Smith, R. Dobie, John R Wilson-Kanamari, M. Halder, Yaoxian Xu, Nazanin Kabgani, Nadine Kaesler, Martin Klaus, Lukas Gernhold, Victor G. Puelles, T. Huber, P. Boor, Sylvia Menzel, R. Hoogenboezem, E. Bindels, J. Steffens, J. Floege, R. Schneider, J. Saez-Rodriguez, N. Henderson, R. Kramann   +28 more
semanticscholar   +1 more source