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Ficolins and the lectin complement pathway [PDF]

Immunological Reviews, 2001
Summary:Ficolins, found in various tissues, are a group of proteins containing both a collagen‐like and a fibrinogen‐like domain. Recently, it was shown that ficolins present in serum are lectins with a common binding specificity for N‐acetylglucosamine (GlcNAc). The fibrinogen‐like domain is responsible for the carbohydrate binding.
Teizo Fujita, Misao Matsushita
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Carbohydrate-binding specificities of mouse ficolin A, a splicing variant of ficolin A and ficolin B and their complex formation with MASP-2 and sMAP

Immunogenetics, 2005
Ficolins are a group of proteins mainly consisting of collagen-like and fibrinogen-like domains and are thought to play a role in innate immunity via their carbohydrate-binding activities. Two types of ficolins have been identified in mice, ficolin A, and ficolin B. However, their structure and function are not fully understood.
Yuichi Endo, Daisuke Iwaki, Naomi Nakazawa, Munehiro Nakata, Teizo Fujita, Yu Liu, M. Takahashi, Misao Matsushita   +7 more
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Ficolins in complement activation

Molecular Immunology, 2013
Ficolins are a group of multimeric lectins made up of single subunits each of which is composed of a collagen-like domain and a fibrinogen-like domain. Most of the ficolins identified to date bind to acetylated compounds such as N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc).
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Ficolin A and ficolin B are expressed in distinct ontogenic patterns and cell types in the mouse

Molecular Immunology, 2005
Ficolins are a group of proteins characterized by the presence of collagen-like and fibrinogen-like domains. Two of three human ficolins, L-ficolin and H-ficolin, are serum lectins that form complexes with mannose-binding lectin-associated serine proteases (MASPs) and play important roles in the lectin complement pathway.
Hiroyuki Yaginuma, Shunsaku Homma, Yuichi Endo, Kazuko Kanno, Teizo Fujita, Yu Liu   +5 more
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Abstract 4143606: Ficolin-1 Genetic Polymorphisms in Chronic Chagasic Cardiomyopathy

Circulation
Background: Chagas disease (CD) is an infectious disease caused by the protozoa Trypanosoma cruzi , affecting around 6-7 million people in Latin America. Although most infected individuals remain asymptomatic throughout their lives, annually 2-5% of
Pamela Fontana, Fabiana Andrade, Karita C F Lidani, Helena Placido, Sandra J Catarino, Iara de Messias-Reason   +5 more
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Ficolin‐3 in chronic Chagas disease: Low serum levels associated with the risk of cardiac insufficiency

Parasite immunology (Print), 2021
To investigate whether FCN3 polymorphisms and circulating ficolin‐3 levels were associated with clinical forms of chronic Chagas disease (CD) and to assess their potential use as biomarkers for the disease or its severity.
K. Lidani, F. A. Andrade, M. H. Beltrame, Indira Chakravarti, M. R. Tizzot, E. Cavalcanti, T. Sandri, P. R. Luz, I. D. de Messias-Reason   +8 more
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Hemodialysis leads to plasma depletion of lectin complement pathway initiator molecule ficolin‐2

Hemodialysis international. International Symposium on Home Hemodialysis, 2021
This study aimed to investigate changes in complement system‐related molecules in patients undergoing hemodialysis.
T. L. Nielsen, Katrine Pilely, K. P. Lund, P. Warming, L. L. Plesner, K. Iversen, P. Garred   +6 more
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Characterization of Ficolins as Novel Elastin-Binding Proteins and Molecular Cloning of Human Ficolin-1

Journal of Biochemistry, 1996
A novel elastin-binding protein, EBP-37, was recently identified and purified from human plasma. Its partial amino acid sequences showed significant homology to porcine ficolins, which were originally purified from porcine uterus membranes as multimeric proteins with fibrinogen- and collagen-like domains.
Daisaburo Fujimoto, Yuki Fukumoto, Satoru Harumiya, Satoru Harumiya, Kohsuke Takeda, Hidenori Ichijo, Hiroyuki Tachikawa, Tsukasa Sugiura, Kohei Miyazono   +8 more
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Can ficolin‐2 (L‐ficolin) insufficiency be established by a single serum protein measurement?

International Journal of Immunogenetics, 2015
SummarySerum ficolin‐2 was measured in multiple (2‐27) samples from 68 paediatric sepsis patients. Fourteen individuals (21%) gave values that included a change in status from ‘normal’ to ‘insufficient’ or vice versa. Therefore, if possible, ficolin‐2 concentration should be determined in samples obtained when a disease is inactive.
Jerzy Szczapa, Maciej Cedzynski, David C. Kilpatrick, M. Sobocinski, Anna S. Świerzko, Wojciech Krajewski, Karolina Chojnacka   +6 more
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The ficolin response to LPS-challenge in mice

Molecular Immunology, 2018
The ficolins belong to an important family of pattern recognition molecules, which contributes to complement activation via the lectin pathway. How the ficolins respond to inflammatory stimuli remains only partly understood. In the present study, we investigated the ficolin A and ficolin B expression and protein distribution patterns in a mouse model ...
Ida Jarlhelt, Ninette Genster, Nikolaj Kirketerp-Møller, Mikkel-Ole Skjoedt, Peter Garred   +4 more
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