Results 61 to 70 of about 7,649,591 (233)

Models of field-aligned currents needful to simulate the substorm variations of the electric field and other parameters observed by EISCAT [PDF]

Annales Geophysicae, 1996
We have used the global numerical model of the coupled ionosphere-thermosphere-protonosphere system to simulate the electric-field, ion- and electron-temperature and -concentration variations observed by EISCAT during the substorm event of 25 March ...
M. A. Volkov, A. A. Namgaladze, A. A. Namgaladze   +2 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Small-scale Field-aligned Currents in the Magnetopause Boundary Layer

The Astrophysical Journal
Based on high-resolution measurements from the Magnetospheric Multiscale mission from 2015 May to 2018 June, we statistically investigate the properties of small-scale field-aligned currents (SFACs) in the magnetopause boundary layer.
C. M. Wang, S. Y. Huang, Z. G. Yuan, M. Zhou, K. Jiang, S. B. Xu, Q. Y. Xiong, L. T. Lin   +7 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

A plasma vortex revisited: The importance of including ionospheric conductivity measurements [PDF]

, 2000
In an earlier paper [Kosch et al., 1998], simultaneous all-sky TV imager and Scandinavian Twin Auroral Radar Experiment (STARE) observations of an ionospheric plasma vortex located poleward of an auroral arc were presented.
Kosch, Mike J., Scourfield, M.W.J., Amm, O.   +2 more
core   +3 more sources

Interplanetary Magnetic Field Bx Effect on Field-Aligned Currents in Different Local Times

Remote Sensing
This study explores the impact of the radial interplanetary magnetic field (IMF) on the strength and latitude of peak field-aligned currents (FACs). FACs are derived through vector magnetic field observations of the Swarm satellite mission.
Yu Sun, Hui Wang
doaj   +1 more source