Results 131 to 140 of about 10,818,476 (313)
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Open AgricultureIndonesia is a significant producer of shallots, and the country frequently cultivates three distinct varieties: Bima, Trisula, and Sumenep. Each cultivar exhibits distinct characteristics, specifically when grown under suboptimal conditions.
Kusumiyati Kusumiyati +2 more
doaj +1 more source
Division of Epidemiology and Surveillance Capacity Development 2005 annual report
The Division of Epidemiology and Surveillance Capacity Development (DESCD) 2005 Annual Report is the division\u2019s first annual report, one that reflects the many changes that DESCD and the Centers for Disease Control and Prevention\u2019s (CDC) global
core
Early Grade Literacy in Latin America and the Caribbean: Jamaica Stakeholder Mapping and Analysis
, 2019 The LAC Reads Capacity Program (LRCP) aims to increase the impact, scale, and sustainability of early grade literacy (EGL) activities in priority countries in Latin America and the Caribbean (Jamaica, Haiti, Dominican Republic, Guatemala, Honduras ...
USAID/LAC Reads Capacity Program
core
, 2019 Available Water Capacity (AWC), and field capacity and wilting point volumetric percentages for different soil particle-size classes.
Lisa Nagaoka (7296266) +2 more
core +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Division of Epidemiology and Surveillance Capacity Development 2006 annual report
The Division of Global Public Health Capacity Development (DGPHCD) 2007 Annual Report is the third annual report. Since our last report, several organizational changes have occurred resulting in a name change and the addition of a program to our division.
core
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source