Results 111 to 120 of about 14,521,432 (345)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The effects of water stress and plant density on vegetative and reproductive characteristics of safflower in the semi-arid region

Studia Universitatis Babeș-Bolyai. Biologia
The limited availability of water for irrigation in semi-arid areas necessitates the use of deficit irrigation techniques. Deficit irrigation is an irrigation practice whereby water supply is reduced below maximum levels and a mild water-deficit stress ...
Hasan KOUCHAKKHANI, Mohsen JANMOHAMMADI, Naser SABAGHNIA   +2 more
doaj   +1 more source

Determination of field capacity in the Chibunga and Guano rivers micro-basins. [PDF]

F1000Res, 2021
Mendoza B, Fiallos M, Iturralde S, Santillán P, Guananga N, Bejar J, Lowy DA, Vágó I, Sándor Z.   +8 more
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Updates from the field [PDF]

This electronic quarterly newsletter is produced by CDC\ue2\u20ac\u2122s Division of Public Health Systems and Workforce Development. It aims to inform the international Field Epidemiology Training Programs community about news and events of interest ...

core   +5 more sources

Soil Hydraulic Properties Estimated from Evaporation Experiment Monitored by Low-Cost Sensors

Agronomy
The estimation of soil hydraulic properties—such as water retention and hydraulic conductivity—is essential for irrigation management and agro-hydrological modeling.
Tallys Henrique Bonfim-Silva, Everton Alves Rodrigues Pinheiro, Tonny José Araújo da Silva, Thiago Franco Duarte, Luana Aparecida Menegaz Meneghetti, Edna Maria Bonfim-Silva   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Emergency Simulations: Administrator's guide [PDF]

, 2007
By simulating a disaster humanitarian staff can practice responding to an emergency and collaborating with diverse colleagues in an intense emergency context. The Emergency Capacity Building Project produced this guide to coordinating both 
Klenk, Jeff
core  

Revisiting Field Capacity (FC): variation of definition of FC and its estimation from pedotransfer functions

, 2014
Taking into account the nature of the hydrological processes involved in in situ measurement of Field Capacity (FC), this study proposes a variation of the definition of FC aiming not only at minimizing the inadequacies of its determination, but also at ...
Theophilo Benedicto Ottoni Filho, M. Ottoni, Muriel Bastista de Oliveira, J. Macedo, K. Reichardt   +4 more
semanticscholar   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source