Results 61 to 70 of about 4,332 (272)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Additional file 2: Figure S2. of HiCPlotter integrates genomic data with interaction matrices

, 2015
Whole genome plotting with HiCPlotter. Whole genome interaction profiles displayed with HiCPlotter in wild type (WT) T cells (left) and RAD21 knockout T cells (right). (PDF 187 kb)
Akdemir, Kadir, Chin, Lynda
openaire   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Additional file 3: Figure S3. of HiCPlotter integrates genomic data with interaction matrices

, 2015
Example visualization of 5C interaction data with HiCPlotter. Interaction matrices of mouse embryonic stem cells (mESC), mESCs with Xist deletion (mESC_XO) and mouse embryonic fibroblast cells (MEF) displayed as heatmaps (a) and rotated half matrix (b), in which the range of the rotated half matrix is 50 bins from the diagonal. (PDF 219 kb)
Akdemir, Kadir, Chin, Lynda
openaire   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Perfil cognitivo de estudiantes con bajo rendimiento intelectual. Asociaciones entre inteligencia y creatividad

Actualidades Investigativas en Educación
El estudiantado con bajo rendimiento intelectual se caracteriza por presentar alteraciones en distintas áreas del funcionamiento cognitivo, académico y conductual.
Blanca Ivet Chávez Soto, Edgar Grimaldo Salazar, Alma Castillo Granados, Italia Valeria Rodríguez Reyes   +3 more
doaj   +1 more source

Additional file 8: Figure S8. of HiCPlotter integrates genomic data with interaction matrices

, 2015
Annotating the interaction matrices by marking significantly interacting loci with circles. Interaction matrices of GM12878, KBM7, K562, HUVEC, IMR90, HMEC, and NHEK cells displayed as heatmaps. Circles (cyan) on the interaction matrices are identified as significantly interacting loci (HiCCUP peaks) and can be used for annotating certain regions on ...
Akdemir, Kadir, Chin, Lynda
openaire   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Additional file 9: Figure S9. of HiCPlotter integrates genomic data with interaction matrices

, 2015
Cohesin ChIA-PET interactions are enriched in early replication domains. a Density plot represents distribution of Repli-Seq signal for RAD21 ChIA-PET ends (blue), whole genome distribution of Repli-Seq data (red), and randomly selected regions (yellow) in GM12878 cells.
Akdemir, Kadir, Chin, Lynda
openaire   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source