Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Are the Cognitive Processes Underlying Practical Intelligence Redundant with Those Underlying Traditional Intelligence [PDF]
, 2000 non
Rauscher, Shari
core +1 more source
Working memory training in older adults: Bayesian evidence supporting the absence of transfer [PDF]
, 2017 The question of whether working memory training leads to generalized improvements in untrained cognitive abilities is a longstanding and heatedly debated one.
Guye, S., Von Bastian, Claudia C.
core +2 more sources
Additional file 4: Figure S4. of HiCPlotter integrates genomic data with interaction matrices
, 2015 Example visualization of 4C and ChIP-Seq data as histograms with HiCPlotter. Interaction matrix of mouse embryonic stem cells displayed as heatmaps (a) and rotated half matrix (b), in which the range of the rotated half matrix is 8 megabases from the diagonal.
Akdemir, Kadir, Chin, Lynda
openaire +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Improvements and future challenges for the research infrastructure in the field “Measuring cognitive ability” [PDF]
The assessment of cognitive abilities is critical in large-scale survey studies that aim at elucidating the longitudinal interplay between the individual’s cognitive potential and socio-economic variables.
Elsbeth Stern, Roland H. Grabner
core
Common process demands of two complex dynamic control tasks : Transfer is mediated by comprehensive strategies [PDF]
, 2017 Although individual differences in complex problem solving (CPS) are well–established, relatively little is known about the process demands that are common to different dynamic control (CDC) tasks. A prominent example is the VOTAT strategy that describes
Fischer, Andreas, Schoppek, Wolfgang
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COMPOSITION MATRICES - GEOMETRIC FIGURE
Modern problems of modeling, 2023 Pavlenko O +3 more
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Additional file 6: Figure S6. of HiCPlotter integrates genomic data with interaction matrices
, 2015 Example usage of tiles for presenting tissue-specific enhancer locations with HiCPlotter. a Interaction matrix of mouse embryonic stem cells displayed as a heatmap. b Histograms represent 4C genomic assay signals: two tracks are displayed for Hoxa13 interactions in mouse E12.5 digits (Digits) and in mouse E15.5 genitals (GT).
Akdemir, Kadir, Chin, Lynda
openaire +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source