Results 51 to 60 of about 3,615 (234)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Transfer after process-based object-location memory training in healthy older adults [PDF]
, 2016 A substantial part of age-related episodic memory decline has been attributed to the decreasing ability of older adults to encode and retrieve associations among simultaneously processed information units from long-term memory.
Eschen, A. +4 more
core +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Working memory training in older adults: Bayesian evidence supporting the absence of transfer [PDF]
, 2017 The question of whether working memory training leads to generalized improvements in untrained cognitive abilities is a longstanding and heatedly debated one.
Guye, S., Von Bastian, Claudia C.
core +2 more sources
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Food for thought: Association between dietary tyrosine and cognitive performance in younger and older adults [PDF]
, 2019 The fact that tyrosine increases dopamine availability that, in turn, may enhance cognitive performance has led to numerous studies on healthy young participants taking tyrosine as a food supplement. As a result of this dietary intervention, participants
Brandmaier, A. +7 more
core +3 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Actualidades Investigativas en EducaciónEl estudiantado con bajo rendimiento intelectual se caracteriza por presentar alteraciones en distintas áreas del funcionamiento cognitivo, académico y conductual.
Blanca Ivet Chávez Soto +3 more
doaj +1 more source
Cortical Dynamics of Visual Motion Perception: Short-Range and Long Range Apparent Motion [PDF]
, 1991 This article describes further evidence for a new neural network theory of biological motion perception that is called a Motion Boundary Contour System. This theory clarifies why parallel streams Vl-> V2 and Vl-> MT exist for static form and motion form ...
Grossberg, Stephen, Rudd, Michael E.
core +3 more sources
Changes in neuropsychological functioning following temporal lobectomy in patients with temporal lobe epilepsy [PDF]
, 2009 Purpose: This study was conducted to evaluate the changes in neuropsychological functioning in patients with temporal lobe epilepsy (TLE) after temporal lobe resection.
Chung, C. +6 more
core +2 more sources