Results 111 to 120 of about 21,702 (299)

PEG‐23 glyceryl distearate, a multifunctional skin‐supporting material, upregulates the expression of factors associated with epidermal barrier and hydration

International Journal of Cosmetic Science, EarlyView.
Polyethylene glycol‐23 glyceryl distearate (GDS‐23) forms niosomes and penetrates the skin. Our results suggest that the pharmacological effects following dermal penetration of GDS‐23 may enhance skin homeostasis by improving barrier function and moisture retention.
Tatsuro Miyoshi, Brian C. Keller, Sui Nakagawa, Takashi Ashino, Satoshi Numazawa   +4 more
wiley   +1 more source

Mutations in the filaggrin gene and food allergy

Gastroenterology Review, 2014
The results of long-term epidemiological studies show that the number of people suffering from allergic diseases, especially from food allergies and atopic dermatitis (AD), is still increasing. Although the research thus far has been conducted mainly in Europe, North America, and Asia, there are also data appearing from the first studies in that field ...
Anna Maria Ogrodowczyk, Lidia Hanna Markiewicz, Barbara Wróblewska   +2 more
openaire   +3 more sources

10-Hydroxy-2-Decenoic Acid in Royal Jelly Extract Induced Both Filaggrin and Amino Acid in a Cultured Human Three-Dimensional Epidermis Model

Cosmetics, 2017
Royal jelly (RJ) is a natural product which the honeybee secretes as a special diet for a queen bee. It is one of the natural products in which various functionalities, such as antibacterial effects, immunomodulating properties, and estrogen-like action,
Lihao Gu, Haifeng Zeng, Kazuhisa Maeda
doaj   +1 more source

European Guideline (EuroGuiDerm) on atopic eczema: Living update

Journal of the European Academy of Dermatology and Venereology, EarlyView.
The updated guideline includes a new evidence‐based recommendation for the IL‐13 inhibitor lebrikizumab. In addition, the Janus kinase inhibitors baricitinib and abrocitinib, which were initially only approved for adult patients, are now also recommended for children from the age of 2 and adolescents from the age of 12, respectively.
A. Wollenberg, M. Kinberger, B. Arents, N. Aszodi, S. Barbarot, T. Bieber, H. A. Brough, P. Calzavara‐Pinton, S. Christen‐Zaech, M. Deleuran, M. Dittmann, N. Fosse, K. Gáspár, L. A. A. Gerbens, U. Gieler, G. Girolomoni, S. Gregoriou, S. Holland, C. G. Mortz, A. Nast, U. Nygaard, E. M. Rehbinder, J. Ring, M. Rossi, E. Serra‐Baldrich, D. Simon, Z. Z. Szalai, J. C. Szepietowski, A. Torrelo, T. Werfel, R. N. Werner, C. Flohr   +31 more
wiley   +1 more source

Treatment with Docosahexaenoic Acid Improves Epidermal Keratinocyte Differentiation and Ameliorates Inflammation in Human Keratinocytes and Reconstructed Human Epidermis Models

Molecules, 2019
Atopic dermatitis (AD) is a chronic inflammatory skin disease that can cause skin barrier function damage. Although co-incubation with docosahexaenoic acid (DHA) exerts a positive effect on deficient skin models, no studies have investigated the effects ...
Tinghan Jia, Wu Qiao, Qifeng Yao, Wenhui Wu, Ken Kaku   +4 more
doaj   +1 more source

Changes in nano-mechanical properties of human epidermal cornified cells in children with atopic dermatitis [version 2; peer review: 2 approved]

Wellcome Open Research, 2020
Background: Impaired skin barrier is an important etiological factor in atopic dermatitis (AD). The structural protein filaggrin (FLG) plays a major role in maintenance of the competent skin barrier and its deficiency is associated with enhanced ...
Marek Haftek, Maeve A McAleer, Ivone Jakasa, WH Irwin McLean, Sanja Kezic, Alan D. Irvine   +5 more
doaj   +1 more source

Evidence for the critical role of the PI3K signaling pathway in particulate matter-induced dysregulation of the inflammatory mediators COX-2/PGE2 and the associated epithelial barrier protein Filaggrin in the bronchial epithelium

Cell Biology and Toxicology, 2019
Particulate matter (PM) is an environmental pollutant closely associated with human airway inflammation. However, the molecular mechanisms of PM-related airway inflammation remains to be fully elucidated. It is known that COX-2/PGE2 play key roles in the
Chenjian Song, Lingjing Liu, Junjie Chen, Yiran Hu, Jingli Li, Beibei Wang, S. Bellusci, Chengshui Chen, Nian Dong   +8 more
semanticscholar   +1 more source

Th2 mRNA gene expression analysis separates Prurigo nodularis into two immune signature groups

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Protein expression, histology and RNA analyses were performed from patients with prurigo nodularis (PN). All patients had typical PN characteristics. Lymphocytes/monocytes demonstrated more frequent positive staining signals in lesional versus non‐lesional samples for IL‐31, IL‐31RA, OSM and OSMRb.
Sonja Ständer, Emma Guttman‐Yassky, Gil Yosipovitch, Henning Wiegmann, Dieter Metze, Madeline Kim, Ester Del Duca, Kent Bondensgaard, John F. Paolini, The LOTUS‐PN Investigators Group, David Pariser, Gil Yosipovitch, Adam Friedman, Timothy Berger, Brian Kim, Jonathan Silverberg, Maria Alora‐Palli, Swarna Ekanayake‐Bohlig, Sonja Ständer, Jacek Szepietowski, Elke Weisshaar   +20 more
wiley   +1 more source

Functional and proteomic analysis of a full thickness filaggrin-deficient skin organoid model

Wellcome Open Research, 2019
Background: Atopic eczema is an itchy inflammatory disorder characterised by skin barrier dysfunction. Loss-of-function mutations in the gene encoding filaggrin ( FLG) are a major risk factor, but the mechanisms by which filaggrin haploinsufficiency ...
M. Elias, S. Wright, W. V. Nicholson, Kimberley Morrison, A. Prescott, S. ten Have, P. Whitfield, A. Lamond, S. Brown   +8 more
semanticscholar   +1 more source

Patients With Atopic Dermatitis Show Increased Clonal Hematopoiesis and Risk of Hematological Cancer

Allergy, EarlyView.
Verena Vogi, Emina Jukic, Robert Gruber, Andre Fiona, Deborah Minzaghi, Johannes Zschocke, Sandrine Dubrac   +6 more
wiley   +1 more source