Results 111 to 120 of about 21,508 (266)

Postbiotics and Nicotinamide Utilize Distinct Mechanisms to Improve Skin Barrier Integrity, Inflammation, and Keratinocyte Differentiation

Allergy, EarlyView.
Integrating skin barrier measurements with omics and machine learning, we found that postbiotics and NAM regulate skin homeostasis through distinct, strain‐ and dose‐dependent mechanisms. Postbiotics primarily modulate skin barrier function by promoting keratinocyte differentiation and suppressing inflammation.
Yagiz Pat, Duygu Yazici, Huseyn Babayev, Sena Ardicli, Xiangting Bu, Sheri Simmons, Anthony Almada, Christine Avena, Tye Jensen, Raja Dhir, Patrick Westermann, Asuncion Garcia‐Sanchez, Manru Li, Ozge Ardicli, Can Zeyneloglu, Marco Pane, Angela Amoruso, Christoph Messner, Ismail Ogulur, Yasutaka Mitamura, Mubeccel Akdis, Cezmi A. Akdis   +21 more
wiley   +1 more source

LD Hub:a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis [PDF]

, 2017
Motivation: LD score regression is a reliable and efficient method of using genome-wide association study (GWAS) summary-level results data to estimate the SNP heritability of complex traits and diseases, partition this heritability into functional ...
Anttila, V., Bulik-Sullivan, B., Elsworth, B.L., Erzurumluoglu, A.M., EUMODIC Consortium (Heinrich, J.), Evans, D.M, Finucane, H.K., Gaunt, T.R., Haycock, P.C., Hemani, G., Howe, L., Kemp, J.P., Laurin, C., Neale, B.M., Paternoster, L., Price, A.L., St. Pourcain, B., Tansey, K., Warrington, N.M., Zheng, J.   +19 more
core   +2 more sources

Urban particulate matter down-regulates filaggrin via COX2 expression/PGE2 production leading to skin barrier dysfunction

Scientific Reports, 2016
We explored the regulation of filaggrin, cyclooxygenase 2 (COX2) and prostaglandin E2 (PGE2) expression induced by urban particulate matter (PM) in human keratinocytes. In addition, we investigated the signaling pathways involved in PM-induced effects on
Chiang-Wen Lee, Zih-chan lin, Stephen Chu-Sung Hu, Y. Chiang, Lee-Fen Hsu, Yu-Ching Lin, I-Ta Lee, Ming-Horng Tsai, Jia-You Fang   +8 more
semanticscholar   +1 more source

Filaggrin mutations and the skin

Indian Journal of Dermatology, Venereology, and Leprology, 2012
Filaggrin is very important in the terminal differentiation of the skin and the formation of cornified envelope in the stratum corneum. Several mutations in the filaggrin gene have been identified in the last decade, mostly from the European countries.
Dipankar, De, Sanjeev, Handa
openaire   +2 more sources

Anti‐inflammatory effects of physical stimuli: The central role of networks in shaping the future of pharmacological research

British Journal of Pharmacology, EarlyView.
Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi, Reyhaneh Hooshmandabbasi, Alessandro Ravoni, Ying Ma, Luigi Manni, Timothy J. Koh, Caroline Maake, Tiziana Guarnieri, Darong Lai, Vitalii Zablotskii, Christine Nardini   +10 more
wiley   +1 more source

Changes in nano-mechanical properties of human epidermal cornified cells in children with atopic dermatitis [version 2; peer review: 2 approved]

Wellcome Open Research, 2020
Background: Impaired skin barrier is an important etiological factor in atopic dermatitis (AD). The structural protein filaggrin (FLG) plays a major role in maintenance of the competent skin barrier and its deficiency is associated with enhanced ...
Marek Haftek, Maeve A McAleer, Ivone Jakasa, WH Irwin McLean, Sanja Kezic, Alan D. Irvine   +5 more
doaj   +1 more source

Functional and proteomic analysis of a full thickness filaggrin-deficient skin organoid model

Wellcome Open Research, 2019
Background: Atopic eczema is an itchy inflammatory disorder characterised by skin barrier dysfunction. Loss-of-function mutations in the gene encoding filaggrin ( FLG) are a major risk factor, but the mechanisms by which filaggrin haploinsufficiency ...
M. Elias, S. Wright, W. V. Nicholson, Kimberley Morrison, A. Prescott, S. ten Have, P. Whitfield, A. Lamond, S. Brown   +8 more
semanticscholar   +1 more source

Skin Barrier Biomarkers in Patch‐Induced and Clinical Allergic and Irritant Contact Dermatitis

Contact Dermatitis, EarlyView.
Both patch‐induced and clinical ICD and ACD showed consistent alterations in skin barrier‐associated biomarkers, indicative of skin barrier impairment. Among the tested allergens, chromium elicited more pronounced biomarker responses compared to nickel and methylisothiazolinone.
Sanja Kezic, Florentine de Boer, Nariman K. A. Metwally, Karen Ghauharali‐van der Vlugt, Femke S. Beers‐Stet, Wouter Ouwerkerk, Ivone Jakasa, Thomas Rustemeyer, Henk F. van der Molen   +8 more
wiley   +1 more source

Association of Gene Variations POMP, FLG, MTOR and ATG5 gene with the Risk of Asthma in Children

Zdorovʹe Rebenka, 2016
The aim of this study was to determine the correlation between single-nucleotide polymorphisms in the proteasome maturation protein gene (POMP), filaggrin gene (FLG), mammalian target of rapamycin gene (MTOR) and autophagy gene (ATG5) and the development
O.P. Volosovets, S.P. Kryvopustov, O.V. Pavlyk, O.V. Yemets, D.O. Stroi, V.Ye. Dosenko   +5 more
doaj   +1 more source

Assessing Skin Barrier Integrity: A Comparative Study Using Transepidermal Water Loss, Electrical Impedance Spectroscopy and Corneometry

Contact Dermatitis, EarlyView.
This study compares experimental models of human skin barrier disruption and evaluates non‐invasive assessment methods. It highlights electrical impedance spectroscopy (EIS) as a novel tool of quantifying skin barrier damage and supports methodological standardisation and an improved understanding of barrier dysfunction under real‐world conditions ...
Charlotte Jasmin Kiani, Valentina Faihs, Claudia Kugler, Neslim Ercan, Shyami Kandage, Susanne Kaesler, Tilo Biedermann, Knut Brockow   +7 more
wiley   +1 more source