Results 111 to 120 of about 17,078 (216)

Evolutionary origin and diversification of epidermal barrier proteins in amniotes. [PDF]

, 2014
The evolution of amniotes has involved major molecular innovations in the epidermis. In particular, distinct structural proteins that undergo covalent cross-linking during cornification of keratinocytes facilitate the formation of mechanically resilient ...
Alibardi, Lorenzo, Eckhart, Leopold, Eigenheer, Richard A, Hermann, Marcela, Mlitz, Veronika, Rice, Robert H, Strasser, Bettina, Tschachler, Erwin   +7 more
core   +1 more source

Age‐dependent reductions in natural moisturizing factor and caspase‐14 in paediatric atopic dermatitis

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Risa Fukuda, Kyongsun Pak, Hazuki Yasuda, Tomoko Kawai, Kenichiro Hata, Naoko Mochimaru, Marie Takenouchi, Ryo Tanaka, Rena Hashimoto, Yuhki Ueda, Susumu Hashimoto, Keisuke Shimazaki, Kazue Yoshida   +12 more
wiley   +1 more source

CARD14 gain-of-function mutation alone is sufficient to drive IL-23/IL-17-mediated psoriasiform skin inflammation in vivo [PDF]

, 2018
Rare autosomal dominant mutations in the gene encoding the keratinocyte signaling molecule, Caspase Recruitment Domain-Containing Protein 14 (CARD14), have been associated with an increased susceptibility to psoriasis but the physiological impact of ...
Cheng, Phil, Contassot, Emmanuel, French, Lars E, Kiefer, Betina, Meier, Barbara, Mellett, Mark, Mohanan, Deepa, Nobbe, Stephan, Ospelt, Caroline, Satoh, Takashi K, Schairer, Rebekka, Thome, Margot   +11 more
core   +1 more source

Filaggrin Mutations and Allergic Contact Sensitization [PDF]

Journal of Investigative Dermatology, 2008
In this issue, Novak et al. (2008) provide evidence that filaggrin barrier defects might also predispose to allergic contact dermatitis by allowing greater penetration of chemical haptens. Their report provides a fresh perspective on the issues of contact allergy, nickel sensitization, and stratum corneum defects.
openaire   +2 more sources

Restorative effects of camellia oil on the skin-barrier function in a model of DNCB-induced atopic dermatitis

European Journal of Histochemistry
This study aimed to evaluate the therapeutic efficacy of camellia oil on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) in mice, as well as its effect on the expression of skin-barrier-related proteins.
Shicheng Jiao, Lijun Deng, Mu Niu, Jie Yang   +3 more
doaj   +1 more source

HNRNPK maintains epidermal progenitor function through transcription of proliferation genes and degrading differentiation promoting mRNAs. [PDF]

, 2019
Maintenance of high-turnover tissues such as the epidermis requires a balance between stem cell proliferation and differentiation. The molecular mechanisms governing this process are an area of investigation.
Chen, Yifang, Harismendy, Olivier, Jones, Jackson, Li, Jingting, Ling, Ji, Sen, George L, Tiwari, Manisha, Wang, Ying, Xu, Xiaojun   +8 more
core   +1 more source

A minimally invasive tool to study immune response and skin barrier in children with atopic dermatitis [PDF]

, 2019
Background: Atopic dermatitis (AD) affects children of all skin types. Most research has focused on light skin types. Studies investigating biomarkers in people with AD with dark skin types are lacking.
Dontje, B., Hack, D. P., Hasnoe, Q. C. J., Hulshof, L., Jakasa, I., Kezic, S., McLean, W. H. I., Middelkamp-Hup, M. A., Riethmüller, C., Sprikkelman, A. B., van Aalderen, W. M. C., Van't Land, B.   +11 more
core   +3 more sources

Feeding filaggrin: effects of L-histidine supplementation in atopic dermatitis

Clinical, Cosmetic and Investigational Dermatology, 2017
Siao Pei Tan,1,2 Simon B Brown,1,2 Christopher EM Griffiths,3 Richard B Weller,1,2 Neil K Gibbs3,4 1MRC Centre for Inflammation Research, 2Department of Dermatology, The University of Edinburgh, Edinburgh, 3Dermatology Centre, Division of Musculoskeletal
Tan SP, Brown SB, Griffiths CEM, Weller RB, Gibbs NK   +4 more
doaj  

An Aquaporin 3-Notch1 Axis in Keratinocyte Differentiation and Inflammation [PDF]

, 2013
Aquaporin 3 (AQP3) is an aquaglyceroporin which transports water, glycerol and small solutes across the plasma membrane. Its functions are not limited to fluid transport but also involve the regulation of cell proliferation, migration, skin hydration ...
Chen, Hongxiang, Guo, Liqiong, Li, Yongsheng, Sui, Yang, Zhou, Qixing   +4 more
core   +3 more sources

Aspirin-exacerbated respiratory disease is associated with variants in filaggrin, epithelial integrity, and cellular interactions

Journal of Allergy and Clinical Immunology: Global
Background: Previous studies have determined that up to 6% of patients with aspirin-exacerbated respiratory disease (AERD) have family history of AERD, indicating a possible link with genetic polymorphisms.
Elina Jerschow, MD, MSc, Robert Dubin, PhD, Chien-Chang Chen, PhD, Alex iAkushev, MSc, Esha Sehanobish, PhD, Mohammad Asad, PhD, Sergio E. Chiarella, MD, Steven A. Porcelli, MD, John Greally, DMed, PhD   +8 more
doaj   +1 more source