Results 51 to 60 of about 21,702 (299)

A de novo variant in the ASPRV1 gene in a dog with ichthyosis. [PDF]

PLoS Genetics, 2017
Ichthyoses are a heterogeneous group of inherited cornification disorders characterized by generalized dry skin, scaling and/or hyperkeratosis. Ichthyosis vulgaris is the most common form of ichthyosis in humans and caused by genetic variants in the FLG ...
Anina Bauer, Dominik P Waluk, Arnaud Galichet, Katrin Timm, Vidhya Jagannathan, Beyza S Sayar, Dominique J Wiener, Elisabeth Dietschi, Eliane J Müller, Petra Roosje, Monika M Welle, Tosso Leeb   +11 more
doaj   +1 more source

Dysbiotic Lesional Microbiome With Filaggrin Missense Variants Associate With Atopic Dermatitis in India

Frontiers in Cellular and Infection Microbiology, 2020
Background: Atopic Dermatitis (AD) has been associated with the loss of function (LoF) mutations in Filaggrin (FLG) gene and increase in relative abundance of specific microbes in the lesional skin, predominantly in Caucasians.
S. Nath, Naina Kumari, D. Bandyopadhyay, Neloy Sinha, P. Majumder, Rupak Mitra, S. Mukherjee   +6 more
semanticscholar   +1 more source

Filaggrin mutations and the skin

Indian Journal of Dermatology, Venereology, and Leprology, 2012
Filaggrin is very important in the terminal differentiation of the skin and the formation of cornified envelope in the stratum corneum. Several mutations in the filaggrin gene have been identified in the last decade, mostly from the European countries.
Sanjeev Handa, Dipankar De
openaire   +2 more sources

Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis. [PDF]

, 2019
Chronic itch remains a highly prevalent disorder with limited treatment options. Most chronic itch diseases are thought to be driven by both the nervous and immune systems, but the fundamental molecular and cellular interactions that trigger the ...
Barton, Gregory M, Bautista, Diana M, Brem, Rachel B, Brock, Emily C, Deguine, Jacques, Gronert, Karsten, Hill, Rose Z, Kucirek, Natalie, Rifi, Ziad, Schwendinger-Schreck, Jamie, Walsh, Carolyn M, Wei, Jessica   +11 more
core   +1 more source

Expression of Filaggrin in Normal and Keratinized Conjunctiva [PDF]

The Open Ophthalmology Journal, 2012
We wanted to investigate filaggrin expression in normal conjunctiva and in conjunctiva exposed to different degrees of mechanical stress. Mechanical stress results in parakeratinization of the conjunctiva. If filaggrin is expressed in the milder forms of parakeratinization, it might be used as a sensitive marker of mechanical stress.Immunohistochemical
Lund, Anne Sofie Kragegaard, Heegaard, Steffen, Prause, Jan Ulrik, Toft, Peter Bjerre, Skov, Lone   +4 more
openaire   +4 more sources

Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial. [PDF]

, 2020
BACKGROUND: Skin barrier dysfunction precedes eczema development. We tested whether daily use of emollient in the first year could prevent eczema in high-risk children. METHODS: We did a multicentre, pragmatic, parallel-group, randomised controlled trial
BEEP study team, Boyle, RJ, Bradshaw, LE, Brown, SJ, Chalmers, JR, Cork, MJ, Davies-Jones, S, Flohr, C, Haines, RH, Jay, N, Kelleher, MM, Lawton, S, Mitchell, EJ, Montgomery, AA, Perkin, MR, Ridd, MJ, Sach, TH, Simpson, EL, Swinden, R, Tarr, S, Thomas, KS, Williams, HC   +21 more
core   +7 more sources

Studies Using Antibodies against Filaggrin and Filaggrin 2 in Canine Normal and Atopic Skin Biopsies

Animals
Filaggrin is important for the skin barrier and atopic dermatitis. Another filaggrin-like protein, filaggrin 2, has been described. We evaluated antibodies against both filaggrins in normal and atopic skin biopsies from dogs before and after allergen ...
Rosanna Marsella, Kim Ahrens, Rachel Wilkes   +2 more
doaj   +1 more source

Functional Significance of Single-Nucleotide Polymorphism (rs11204981) in Filaggrin (flg) Gene for the Treatment of Bronchial Asthma in Children with Atopic Dermatitis

Zdorovʹe Rebenka, 2015
Objective. The objective of this study was to determine the correlation between single-nucleotide polymorphism in filaggrin gene and expression of filaggrin mRNA in buccal epithelium and the phenotype of bronchial asthma with atopic dermatitis in medical
O.P. Volosovets, V.Ye. Dosenko, S.P. Kryvopustov, O.V. Pavlyk, O.V. Yemets, D.O. Stroi   +5 more
doaj   +1 more source

Filaggrin loss-of-function mutations and atopic dermatitis as risk factors for hand eczema in apprentice nurses:part II of a prospective cohort study [PDF]

, 2013
BACKGROUND/OBJECTIVES: Environmental exposure and personal susceptibility both contribute to the development of hand eczema. In this study, we investigated the effect of loss-of-function mutations in the filaggrin gene (FLG), atopic dermatitis and wet ...
Bakker, Jan G., Bos, Jan D., Calkoen, Florentine, Campbell, Linda E., Kezic, Sanja, McLean, W. H. Irwin, Van Dijk, Frank J. H., Verberk, Maarten M., Visser, Maaike J.   +8 more
core   +2 more sources

Role of Filaggrin in Pediatric Allergology

Zdorovʹe Rebenka, 2013
There had been found strong evidence that a violation of the epidermal barrier is a necessary condition for the development of sensitivity to allergens.
A.P. Volosovets, S.P. Krivopustov, Ye.V. Pavlik   +2 more
doaj   +1 more source