Results 51 to 60 of about 21,508 (266)

Consensus on the Clinical Approach to Moderate-to-Severe Atopic Dermatitis in Spain: A Delphi Survey [PDF]

, 2020
Background. The purpose of this study was to gather information on the current assessment and management of patients with moderate-to-severe AD in routine daily practice. Methods.
Armario Hita, José Carlos, Baldrich, Esther Serra, Herráez, L., Jáuregui, Ignacio, Martín-Santiago, Ana, Ortiz de Frutos, Javier, Sastre, Joaquin, Silvestre, Juan Francisco, Universitat Autònoma de Barcelona, Valero, Antonio   +9 more
core   +3 more sources

Studies Using Antibodies against Filaggrin and Filaggrin 2 in Canine Normal and Atopic Skin Biopsies

Animals
Filaggrin is important for the skin barrier and atopic dermatitis. Another filaggrin-like protein, filaggrin 2, has been described. We evaluated antibodies against both filaggrins in normal and atopic skin biopsies from dogs before and after allergen ...
Rosanna Marsella, Kim Ahrens, Rachel Wilkes   +2 more
doaj   +1 more source

Role of Filaggrin in Pediatric Allergology

Zdorovʹe Rebenka, 2013
There had been found strong evidence that a violation of the epidermal barrier is a necessary condition for the development of sensitivity to allergens.
A.P. Volosovets, S.P. Krivopustov, Ye.V. Pavlik   +2 more
doaj   +1 more source

In silico analysis of the profilaggrin sequence indicates alterations in the stability, degradation route, and intracellular protein fate in filaggrin null mutation carriers

Frontiers in Molecular Biosciences, 2023
Background: Loss of function mutation in FLG is the major genetic risk factor for atopic dermatitis (AD) and other allergic manifestations. Presently, little is known about the cellular turnover and stability of profilaggrin, the protein encoded by FLG ...
Argho Aninda Paul, Natalia A. Szulc, Adrian Kobiela, Sara J. Brown, Wojciech Pokrzywa, Danuta Gutowska-Owsiak   +5 more
doaj   +1 more source

Filaggrin loss-of-function mutations and atopic dermatitis as risk factors for hand eczema in apprentice nurses:part II of a prospective cohort study [PDF]

, 2013
BACKGROUND/OBJECTIVES: Environmental exposure and personal susceptibility both contribute to the development of hand eczema. In this study, we investigated the effect of loss-of-function mutations in the filaggrin gene (FLG), atopic dermatitis and wet ...
Bakker, Jan G., Bos, Jan D., Calkoen, Florentine, Campbell, Linda E., Kezic, Sanja, McLean, W. H. Irwin, Van Dijk, Frank J. H., Verberk, Maarten M., Visser, Maaike J.   +8 more
core   +2 more sources

Real-time PCR quantification of the canine filaggrin orthologue in the skin of atopic and non-atopic dogs: a pilot study

BMC Research Notes, 2011
Background Canine atopic dermatitis (AD) is a common inflammatory skin disease associated with defects in the epidermal barrier, particularly in West Highland white terriers (WHWTs).
Roque Joana, O'Leary Caroline A, Kyaw-Tanner Myat, Duffy David L, Shipstone Michael   +4 more
doaj   +1 more source

The immunological and structural epidermal barrier dysfunction and skin microbiome in atopic dermatitis-an update

Frontiers in Molecular Biosciences, 2023
Atopic dermatitis (AD) is a common, chronic and relapsing inflammatory skin disease with various clinical presentations and combinations of symptoms. The pathophysiology of AD is complex and multifactorial.
Tubanur Çetinarslan, Lisa Kümper, Regina Fölster-Holst   +2 more
doaj   +1 more source

Functional Significance of Single-Nucleotide Polymorphism (rs11204981) in Filaggrin (flg) Gene for the Treatment of Bronchial Asthma in Children with Atopic Dermatitis

Zdorovʹe Rebenka, 2015
Objective. The objective of this study was to determine the correlation between single-nucleotide polymorphism in filaggrin gene and expression of filaggrin mRNA in buccal epithelium and the phenotype of bronchial asthma with atopic dermatitis in medical
O.P. Volosovets, V.Ye. Dosenko, S.P. Kryvopustov, O.V. Pavlyk, O.V. Yemets, D.O. Stroi   +5 more
doaj   +1 more source

Ni2+-Assisted Hydrolysis May Affect the Human Proteome; Filaggrin Degradation Ex Vivo as an Example of Possible Consequences

Frontiers in Molecular Biosciences, 2022
Deficiency in a principal epidermal barrier protein, filaggrin (FLG), is associated with multiple allergic manifestations, including atopic dermatitis and contact allergy to nickel.
Ewa Izabela Podobas, Ewa Izabela Podobas, Ewa Izabela Podobas, Danuta Gutowska-Owsiak, Danuta Gutowska-Owsiak, Sébastien Moretti, Jarosław Poznański, Mariusz Kulińczak, Marcin Grynberg, Aleksandra Gruca, Arkadiusz Bonna, Dawid Płonka, Tomasz Frączyk, Graham Ogg, Wojciech Bal   +14 more
doaj   +1 more source

Aryl hydrocarbon receptor activation restores filaggrin expression via OVOL1 in atopic dermatitis

Cell Death and Disease, 2017
Filaggrin (FLG) mutation is a well-confirmed genetic aberration in atopic dermatitis (AD). Genome-wide association studies on AD have revealed other susceptibility genes, for example, Ovo-like 1 (OVOL1). Nonetheless, the relation between FLG and OVOL1 is
G. Tsuji, A. Hashimoto-Hachiya, Mari Kiyomatsu-Oda, M. Takemura, F. Ohno, Takamichi Ito, Saori Morino-Koga, C. Mitoma, T. Nakahara, H. Uchi, M. Furue   +10 more
semanticscholar   +1 more source