Results 81 to 90 of about 17,078 (216)
Acta Dermato-Venereologica, 2017 Epidermal filaggrin level is affected by ultraviolet B irradiation in animal and experimental models. This study examined the effect of ultraviolet B irradiation on epidermal filaggrin and natural moisturizing factors in vivo in healthy adults (n = 22 ...
Stine Simonsen +4 more
doaj +1 more source
Journal of the Royal College of Physicians of Edinburgh, 2008 Recent genetic findings demonstrate an important role for the epidermal protein filaggrin in the aetiology of atopic diseases, including asthma as well as eczema. Filaggrin is critical to the conversion of keratinocytes to the protein/lipid squames that compose the stratum corneum, the outermost barrier layer of the skin.
null R Weller, null WHI McLean
openaire +1 more source
TSLP is a direct trigger for T cell migration in filaggrin-deficient skin equivalents
Scientific Reports, 2017 Mutations in the gene encoding for filaggrin (FLG) are major predisposing factors for atopic dermatitis (AD). Besides genetic predisposition, immunological dysregulations considerably contribute to its pathophysiology.
Leonie Wallmeyer +6 more
doaj +1 more source
Clinical presentation of atopic dermatitis by filaggrin gene mutation status during the first 7 years of life in a prospective cohort study. [PDF]
PLoS ONE, 2012 BackgroundFilaggrin null mutations result in impaired skin barrier functions, increase the risk of early onset atopic dermatitis and lead to a more severe and chronic disease.
Charlotte Giwercman Carson +4 more
doaj +1 more source
, 2016 Atopic eczema is an itchy inflammatory skin disease with a chronic relapsing–remitting course; it has increased in prevalence in recent decades and now affects up to 25% of school-aged children in the developed world and up to 10% of adults.
Deckert +7 more
core +2 more sources
Contact Sensitization in Adults With Atopic Dermatitis: A 21‐Year Single‐Center Tertiary Experience
Contact Dermatitis, EarlyView.A graphical abstract has been included as supplemental material. ABSTRACT Background Atopic dermatitis is a common chronic inflammatory skin condition. Data on contact sensitization in adults with atopic dermatitis remain limited. Objectives To investigate the prevalence of contact sensitization in adults with and without AD: Patients/Methods A ...
Francesca Caroppo +5 more
wiley +1 more source
Role of FGFR2b expression and signaling in keratinocyte differentiation. Sequential involvement of PKCδ and PKCα [PDF]
, 2018 The tumor suppressor epithelial isoform of the fibroblast growth factor receptor 2 (FGFR2b) induces human keratinocyte early differentiation. Moreover, protein kinases C (PKCs) are known to regulate the differentiation program in several cellular ...
Belleudi, Francesca +4 more
core +2 more sources
A review of skin microbiome and new challenges to cosmetic microbiome‐friendly formulations
International Journal of Cosmetic Science, EarlyView.Microbiome‐friendly concepts offer new perspectives for a healthy relationship between cosmetic use and the skin microbiome, especially the interaction of non‐biotic cosmetic ingredients with the skin, requiring further studies to clarify the dynamics between the skin microbiome and different classes of cosmetic ingredients.
Yasmin Rosa Santos +3 more
wiley +1 more source
Human and computational models of atopic dermatitis:A review and perspectives by an expert panel of the International Eczema Council [PDF]
, 2018 Atopic dermatitis (AD) is a prevalent disease worldwide and is associated with systemic comorbidities representing a significant burden on patients, their families, and society. Therapeutic options for AD remain limited, in part because of a lack of well-
Bieber, Thomas +15 more
core +5 more sources
Biomarkers for therapeutic response and adverse outcomes in atopic dermatitis: A systematic review
Journal of the European Academy of Dermatology and Venereology, EarlyView.This review assessed 52 biomarkers predicting systemic therapy response and adverse events in atopic dermatitis. Most studies focused on dupilumab, and findings were inconsistent. IgE and eosinophils were largely non‐predictive, though elevated eosinophils and LDH sometimes indicated poorer outcomes.
Eva Hilger +11 more
wiley +1 more source