Results 41 to 50 of about 35,622 (198)

Proteomic Analysis of Dendritic Filopodia-Rich Fraction Isolated by Telencephalin and Vitronectin Interaction

Frontiers in Synaptic Neuroscience, 2018
Dendritic filopodia are thin, long, and highly mobile protrusions functioning as spine precursors. By contrast with a wealth of knowledge on molecular profiles in spines, little is known about structural and functional proteins present in dendritic ...
Yutaka Furutani, Yoshihiro Yoshihara, Yoshihiro Yoshihara   +2 more
doaj   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

Extracellular Mipp1 Activity Confers Migratory Advantage to Epithelial Cells during Collective Migration

Cell Reports, 2015
Multiple inositol polyphosphate phosphatase (Mipp), a highly conserved but poorly understood histidine phosphatase, dephosphorylates higher-order IPs (IP4–IP6) to IP3.
Yim Ling Cheng, Deborah J. Andrew
doaj   +1 more source

The Effects of Mechanical Stretch on Integrins and Filopodial-Associated Proteins in Normal and Glaucomatous Trabecular Meshwork Cells

Frontiers in Cell and Developmental Biology, 2022
The trabecular meshwork (TM) is the tissue responsible for regulating aqueous humor fluid egress from the anterior eye. If drainage is impaired, intraocular pressure (IOP) becomes elevated, which is a primary risk factor for primary open angle glaucoma ...
Yong-Feng Yang, Ying Ying Sun, Donna M. Peters, Kate E. Keller, Kate E. Keller   +4 more
doaj   +1 more source

Graphene Layers as Functional Biomaterials. From Fabrication and Characterization to Biological Applications

Advanced Materials Interfaces, EarlyView.
Graphene layers are fabricated on Cu foil and transferred onto glass substrates to form double‐ and multi‐layer G‐glass. Raman spectroscopy confirms structural integrity, while SEM and fluorescence microscopy reveal favorable adhesion and spreading of L‐929 fibroblast cells.
Mariana Mihaela Apostol, Issam Boukhoubza, Daniela Oprea, Iulia Corina Ciobotaru, Catalin Negrila, Ionut Enculescu, Ecaterina Andronescu, Teodor Adrian Enache, Elena Matei   +8 more
wiley   +1 more source

Filopodia formation induced by active mDia2/Drf3 [PDF]

, 2008
Filopodia are rod-shaped cell surface protrusions composed of a parallel bundle of actin filaments. Since filopodia frequently emanate from lamellipodia, it has been proposed that they form exclusively by the convergence and elongation of actin filaments
T.E.B. STRADAL, Köstler, S.A.; id_orcid, J. FAIX, Geffers, Robert, Faix, J., K. ROTTNER, Rottner, K., Urban, E, Hänisch, J., Geffers, R., Köstler, S A, J.V. SMALL, Block, J., Small, J.V., E. URBAN, Urban, E., J. BLOCK, Small, J V, Stradal, T E B, Stradal, T.E.B., R. GEFFERS, S.A. KÖSTLER, J. HÄNISCH, Block, J, Faix, J, Hänisch, J, Rottner, K   +26 more
core   +1 more source

Theoretical model of membrane protrusions driven by curved active proteins

Frontiers in Molecular Biosciences, 2023
Eukaryotic cells intrinsically change their shape, by changing the composition of their membrane and by restructuring their underlying cytoskeleton. We present here further studies and extensions of a minimal physical model, describing a closed vesicle ...
Yoav Ravid, Samo Penič , Yuko Mimori-Kiyosue, Shiro Suetsugu, Shiro Suetsugu, Shiro Suetsugu, Aleš Iglič, Nir S. Gov   +7 more
doaj   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Targeting of dopamine transporter to filopodia requires an outward-facing conformation of the transporter

Scientific Reports, 2017
Dopamine transporter (DAT) has been shown to accumulate in filopodia in neurons and non-neuronal cells. To examine the mechanisms of DAT filopodial targeting, we used quantitative live-cell fluorescence microscopy, and compared the effects of the DAT ...
Shiqi Ma, Mary H. Cheng, Daryl A. Guthrie, Amy H. Newman, Ivet Bahar, Alexander Sorkin   +5 more
doaj   +1 more source

Functionalized Biomimetic Scaffolds for Human‐Derived Auditory Neural Circuit Construction

Advanced Science, EarlyView.
In Vitro Auditory Circuit Model. ABSTRACT Damage to auditory circuits results in sensorineural hearing loss. However, the scarcity of human inner ear tissue significantly hinders the development of therapies to preserve auditory function, creating a critical need for reliable in vitro models.
Pan Feng, Qian Zhu, Yusong Wang, Hao Rong, Xu Zhang, Fuchun Wang, Tianqi Yu, Wenxuan Wang, Jing Li, Lei Tian, Menghui Liao, Renjie Chai, Yangnan Hu   +12 more
wiley   +1 more source