Results 71 to 80 of about 35,622 (198)
Filopodia: A Rapid Structural Plasticity Substrate for Fast Learning
Frontiers in Synaptic Neuroscience, 2017 Formation of new synapses between neurons is an essential mechanism for learning and encoding memories. The vast majority of excitatory synapses occur on dendritic spines, therefore, the growth dynamics of spines is strongly related to the plasticity ...
Ahmet S. Ozcan
doaj +1 more source
Cellular Mechanisms Enabling Mitochondria Transfer and Transplantation
Advanced Science, EarlyView.Mitochondrial transfer and transplantation (mitoTT) is examined as a multistep process governed by distinct transfer routes and post‐transfer checkpoints. Mechanisms controlling mitochondrial uptake, network integration, cristae remodeling, mtDNA maintenance, immune sensing, and quality control are highlighted, revealing key biological and ...
F. Seyma Gokdemir +3 more
wiley +1 more source
Integrating chemo‐mechanical cues in nano‐microscale environments for stem cell regulation
BMEMat, EarlyView.Nano/microscale control strategies, including nano/microscale materials, ligand spacings, and cell encapsulating gels, cell mechanics, integrin signaling, and biochemical cues to direct stem cell fate, tissue regeneration, and organoid engineering, enabling advanced biomedical applications through mechanoregulation at cell‐material interfaces ...
Rajendra K. Singh +5 more
wiley +1 more source
Cytoskeleton, EarlyView.ABSTRACT Cells sense the stiffness of their extracellular matrix (ECM) and adapt their behavior accordingly. We investigated how ECM stiffness affects the spatial organization of talin1, a key mechanosensitive focal adhesion protein. Using polyacrylamide (PA) hydrogels with tunable stiffnesses (0.2–188 kPa), we analyzed cell morphology, migration ...
Joanna Hajduk +5 more
wiley +1 more source
EMBO ReportsGenes regulating the finger-like cellular protrusions—filopodia have long been implicated in cancer metastasis. However, depleting the flat lamellipodia but retaining filopodia drastically hampers cell migration on spread surface, obscuring the role of ...
Yan Wang +12 more
doaj +1 more source
The role of Rho GTPases in facial morphogenesis
Developmental Dynamics, EarlyView.The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley +1 more source
Notch Signaling: Filopodia Dynamics Confer Robustness [PDF]
, 2010 SummaryThough usually thought of as mediating communication between adjacent cells, Notch–Delta signaling can take place over a longer range through cellular processes known as ‘filopodia’.
Cohen, Stephen M. +3 more
core +1 more source
The Endothelial CXCR Family in Vascular Health and Disease
iNew Medicine, EarlyView.ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu +4 more
wiley +1 more source
Investigating junctional filopodia exchange [PDF]
Metastasis is the leading cause of cancer-related deaths, driven by the ability of cancer cells to migrate from the primary tumour to other parts of the body.
Tammi, Johanna
core
Temporal coupling of axonal calcium responses and filopodia formation
The combination of synaptic structural stability and functional plasticity is a recognized feature of the nervous system. This dichotomy is possible because the processes involved in neuronal information processing, such as receiving and transducing ...
Ivanova, Daniela
core +1 more source