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Status and challenges of filovirus vaccines
Vaccine, 2007Vaccines that could protect humans against the highly lethal Marburg and Ebola viruses have eluded scientists for decades. Classical approaches have been generally unsuccessful for Marburg and Ebola viruses and pose enormous safety concerns as well. Modern approaches, in particular those using vector-based approaches have met with success in nonhuman ...
Mansour Mohamadzadeh, Douglas S. Reed
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Therapeutics Against Filovirus Infection
2017Therapies for filovirus infections are urgently needed. The paradoxical issue facing therapies is the need for rigorous safety and efficacy testing, adhering to the principle tenant of medicine to do no harm, while responding to the extreme for a treatment option during an outbreak. Supportive care remains a primary goal for infected patients. Years of
Gary P. Kobinger +2 more
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Annales de l'Institut Pasteur / Actualités, 1997
Les filovirus, Marburg et Ebola, sont classes au niveau 4 de securite. Leur haute pathogenicite a ete relevee particulierement chez les sous-types Soudan, Zaire et MBGV. Existent plusieurs modes de transmission, le plus frequent etant le contact physique avec le virus.
Heinz Feldmann +2 more
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Les filovirus, Marburg et Ebola, sont classes au niveau 4 de securite. Leur haute pathogenicite a ete relevee particulierement chez les sous-types Soudan, Zaire et MBGV. Existent plusieurs modes de transmission, le plus frequent etant le contact physique avec le virus.
Heinz Feldmann +2 more
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[Haemostasis dysregulation in filovirus infections]
Medecine sciences : M/S, 2015(Uploaded by Plazi for the Bat Literature Project) Filoviruses are responsible for highly lethal infections. Those viruses are found in intertropical areas of Africa and Asia where they circulate in their supposed natural reservoir, fruit bats. During filovirus outbreaks and depending on the strains, various modifications in hemostasis have been ...
Olivier, Reynard +2 more
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Post-exposure therapy of filovirus infections
Trends in Microbiology, 2014Filovirus infections cause fatal hemorrhagic fever characterized by the initial onset of general symptoms before rapid progression to severe disease; the most virulent species can cause death to susceptible hosts within 10 days after the appearance of symptoms. Before the advent of monoclonal antibody (mAb) therapy, infection of nonhuman primates (NHPs)
Gary Wong +4 more
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Filovirus Research: How it Began
2017The first reported filovirus outbreak occurred in August 1967, when laboratory workers in Marburg and Frankfurt, Germany, and Belgrade, Yugoslavia (now Serbia) became infected with an unknown highly pathogenic agent. The disease was characterized by high fever, malaise, rash, hemorrhagic and tetanic manifestations, and high lethality, amounting to 25%.
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Production and Purification of Filovirus Glycoproteins
Ebola (EBOV) and Marburg (MARV) viruses cause hemorrhagic fever disease in humans and non-human primates (NHPs) with case-fatality rates as high as 90%. The 2013-2016 Ebola virus disease (EVD) outbreak led to over 28,000 cases and 11,000 deaths and took an enormous toll on the economy of West African nations, in the absence of any vaccine or ...Madeleine, Noonan-Shueh +2 more
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The Lancet, 1995 Filovirus Structural Biology: The Molecules in the Machine
2017In this chapter, we describe what is known thus far about the structures and functions of the handful of proteins encoded by filovirus genomes. Amongst the fascinating findings of the last decade is the plurality of functions and structures that these polypeptides can adopt.
Erica Ollmann Saphire +3 more
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Journal of the American Veterinary Medical Association, 2009
Kelly L, Warfield +2 more
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Kelly L, Warfield +2 more
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