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Post-exposure therapy of filovirus infections
Trends in Microbiology, 2014Filovirus infections cause fatal hemorrhagic fever characterized by the initial onset of general symptoms before rapid progression to severe disease; the most virulent species can cause death to susceptible hosts within 10 days after the appearance of symptoms. Before the advent of monoclonal antibody (mAb) therapy, infection of nonhuman primates (NHPs)
Gary, Wong +3 more
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Status and challenges of filovirus vaccines
Vaccine, 2007Vaccines that could protect humans against the highly lethal Marburg and Ebola viruses have eluded scientists for decades. Classical approaches have been generally unsuccessful for Marburg and Ebola viruses and pose enormous safety concerns as well. Modern approaches, in particular those using vector-based approaches have met with success in nonhuman ...
Douglas S, Reed, Mansour, Mohamadzadeh
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Filovirus Research: How it Began
2017The first reported filovirus outbreak occurred in August 1967, when laboratory workers in Marburg and Frankfurt, Germany, and Belgrade, Yugoslavia (now Serbia) became infected with an unknown highly pathogenic agent. The disease was characterized by high fever, malaise, rash, hemorrhagic and tetanic manifestations, and high lethality, amounting to 25%.
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Filovirus clearance in non-human primates
The Lancet, 1992There has been concern in the USA and Europe about filovirus outbreaks in recently imported monkeys, and possible transmission to human beings. Healthy monkeys have been found to have low-titre immunofluorescence antibody (IFA) to Asian filoviruses (Reston and Pennsylvania viruses) as well as to the African filoviruses that caused fulminating human ...
S P, Fisher-Hoch +4 more
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Virologie (Montrouge, France)
Since forty years Marburg and Ebola viruses emerge frequently in Africa and are responsible of viral hemorragic fever outbreaks with high mortality rate. Despite intensive research programs, these viruses remain mysterious: the reservoir is not clearly defined, and the mechanisms leading to their high pathogenicity are poorly understood; a defective or
M-C, Georges-Courbot +2 more
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Since forty years Marburg and Ebola viruses emerge frequently in Africa and are responsible of viral hemorragic fever outbreaks with high mortality rate. Despite intensive research programs, these viruses remain mysterious: the reservoir is not clearly defined, and the mechanisms leading to their high pathogenicity are poorly understood; a defective or
M-C, Georges-Courbot +2 more
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Journal of the American Veterinary Medical Association, 2009
Kelly L, Warfield +2 more
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Kelly L, Warfield +2 more
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Quantification of Filovirus Glycoprotein-Specific Antibodies
2017Serological methods such as the enzyme-linked immunosorbent assay (ELISA) and virus neutralization test are fundamental tools used in diagnosis, seroepidemiological studies of filovirus transmission/prevalence, and the evaluation of vaccine immunogenicity and potential therapeutic antibodies.
Wakako, Furuyama +3 more
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Arenavirus, Filovirus, Bunyavirus.
2020Si tratta di tre famiglie di virus accomunati da caratteristiche strutturali, quali il genoma a RNA racchiuso in un nucleocapside a simmetria elicoidale a sua volta circondato da un pericapside. Causano infezioni gravi nell'uomo e in molti vertebrati, che si manifestano spesso come febbri emorragiche dall'esito letale.
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Filovirus Infection in Humanized Mouse Models
Since the discovery of filoviruses in 1967, there have been more than 40 outbreaks with high case-fatality rates causing more than 30,000 deaths in humans. Filovirus disease (FVD) involves the dysregulation of many host physiological processes. While many advances in the field have taken place since the first outbreaks, the dearth of small animal ...Estefanía, Rodríguez +2 more
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