Results 101 to 110 of about 7,588 (203)
Kinetic and Thermodynamic Characterization of the Bacterial Lectin FimH
, 2021 One fundamental aim of drug discovery is the development of new molecular entities that have a considerably advantage over already existing therapies. Urinary tract infections (UTIs) urgently require an alternative to the conventional antibiotic therapy as resistance rates for antibiotics are increasing.
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, 2011 Type 1 fimbriae produced by serovars of Salmonella are characterized by their ability to agglutinate guinea pig erythrocytes in the absence of d-mannose but not in its presence.
Dagmara Kisiela +4 more
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Crystal structure of the FimD usher bound to its cognate FimC-FimH substrate
, 2011 Type 1 pili are the archetypal representative of a widespread class of adhesive multisubunit fibres in Gram-negative bacteria. During pilus assembly, subunits dock as chaperone-bound complexes to an usher, which catalyses their polymerization and ...
Henderson, N.S. +35 more
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Conformational ensembles in Klebsiella pneumoniae FimH impact uropathogenesis
Proceedings of the National Academy of SciencesKlebsiella pneumoniae is an important pathogen causing difficult-to-treat urinary tract infections (UTIs). Over 1.5 million women per year suffer from recurrent UTI, reducing quality of life and causing substantial morbidity and mortality, especially in the hospital setting.
Edward D. B. Lopatto +13 more
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Binding phenotypes of natural S. enterica subspecies I FimH variants.
, 2012 Static adhesion of S. Typhimurium LBH4 transformed with plasmids encoding different variants of FimH or plasmids carrying fimH deletion (fimHΔ) to Man-BSA (red bars) and anti-FimHSE antibody (grey bars). The binding of 3H- labeled bacteria was determined
Dagmara I. Kisiela (159496) +14 more
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Mutations of the fimH gene in E. coli isolates.
, 2019 Mutations of the fimH gene in E. coli isolates.
Chan Hyuk Park (659739) +6 more
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Survival of FimH-expressing enterobacteria in macrophages relies on glycolipid traffic.
, 1997 Strains of Escherichia coli persist within the human gut as normal commensals, but are frequent pathogens and can cause recurrent infection. Here we show that, in contrast to E.
Zhimin Gao +6 more
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, 1999 Mast cells are well known for their harmful role in IgE-mediated hypersensitivity reactions, but their physiological role remains a mystery. Several recent studies have reported that mast cells play a critical role in innate immunity in mice by releasing
Zhimin Gao +4 more
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Phylotype of E. coli according to fimH clades.
, 2013 Phylotype of E. coli according to fimH clades.
Jérémy Denizot (209615) +13 more
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