Results 91 to 100 of about 128,147 (317)

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Les nouvelles missions des centres socioculturels au péril de l’animation

Revue Internationale Animation, Territoires et Pratiques Socioculturelles, 2020
Les centres socioculturels situés sur des territoires qualifiés de problématiques voient en France s’ajouter à leur mission première, l’animation, celles de médiation, d’accueil de populations migrantes, de prévention de la délinquance et avec elles la ...
Louis Schalck
doaj   +1 more source

Climate-Finance

, 2022
It is widely believed that climate change can affect the financial performance of firms. In this chapter, we conceptualise the effects of climate change on the financial performance of firms. We explain that these effects have a twofold justification.
openaire   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Financement des petites et moyennes entreprises : Enjeux et perspectives de lieux

Revue Congolaise des Sciences et Technologies
La survie et le développement de petites et moyennes entreprises demeurent non seulement dans leur capacité managériale, mais aussi dans leur possibilité d’accéder aux ressources financières nécessaires à leur épanouissement.
Jérémie Bompate Mbolotomo, Adolphe-Matthieu Ngalamulume Tshilumbayi, Aimé Manzongo Motukula   +2 more
doaj   +1 more source

Financing of the European Union Budget. [PDF]

This study is concerned with the future financing of the EU budget, including possible budgetary correction mechanisms, and is intended to feed into the budget review.
Begg, Iain, Enderlein, Henrik, Le Cacheux, Jacques, Mrak, Mojmir   +3 more
core  

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Seasoned Equity Offerings by Small and Medium-Sized Enterprises [PDF]

Most of the analyses of small firms’ decision to seek outside equity financing and the conditions thereof have concerned private firms. Knowledge of the risk and return of entrepreneurial ventures for outside investors is consequently limited. This paper
Cécile Carpentier, Jean-François L'Her, Jean-Marc Suret   +2 more
core  

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source