Results 71 to 80 of about 3,695 (266)
Appel pour une allocation intelligente dans le financement du système de santé au Cameroun
The Pan African Medical Journal, 2011 Le Cameroun utilise un système de budgétisation historique et une approche en top - down en pour allouer ses ressources. Le pays compte 175 districts de santé présentant de fortes disparités de nature épidémiologique, économique, géographique et ...
Isidore Sieleunou
doaj +1 more source
Les nouvelles missions des centres socioculturels au péril de l’animation
Revue Internationale Animation, Territoires et Pratiques Socioculturelles, 2020 Les centres socioculturels situés sur des territoires qualifiés de problématiques voient en France s’ajouter à leur mission première, l’animation, celles de médiation, d’accueil de populations migrantes, de prévention de la délinquance et avec elles la ...
Louis Schalck
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
L' Importance du mode de financement dans la pérennité des entreprises familiales algériennes
Academic Finance, 2018 Dans ce papier, nous proposons une esquisse sur la relation entre le mode de financement choisi par l’entreprise familiale et sa pérennité. Dans un premier temps, et à travers une revue de la littérature, nous tenterons de faire le point sur les facteurs
nadia RASSOUL
doaj
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Geopolitic and Geostrategic Intelligence, 2019 Ce papier étudie la relation entre le mode d’organisation des groupes terroristes, la nature de leur financement et le couple « coût-impact » de leurs opérations.
N. ADEL
doaj +1 more source
Journal of Financial and Quantitative Analysis, 2014 AbstractWe find that 43% of firms that make payouts also raise capital during the same year, resulting in 31% of aggregate payouts being externally financed, primarily with debt. Most financed payouts cannot be explained by payout smoothing in response to volatile earnings or investment (rather, they are the result of firms persistently setting payouts
Joan Farre-Mensa +2 more
openaire +2 more sources
Early‐Phase Research in Pediatric Neuro‐Oncology
Pediatric Blood &Cancer, EarlyView.
Jonathan Cunningham
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source