Results 31 to 40 of about 711,500 (260)
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Revue Internationale d’Éducation de Sèvres, 2005 L’éducation est une activité coûteuse qui mobilise une part importante de la richesse produite par les nations. Mettre l’accent sur elle, c’est arbitrer au détriment d’autres usages des ressources sociales.
Jean-Jacques Paul
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Stratégie d’émission des titres publics par le trésor congolais de 2019 à 2023 [PDF]
Mouvements et Enjeux Sociaux, 2023 La qualité d’exécution des dépenses publiques par le Trésor est étroitement liée à la manière dont les ressources sont mobilisées. Plusieurs sources permettent à un Etat de lever les fonds publics pour réaliser ses objectifs ; d’une part, la fiscalité ...
Danny BAPEBABO ILUNGA
doaj
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Funding Nonprofit Radio Technology Initiatives in Canada
Canadian Journal of Nonprofit and Social Economy Research, 2019 Media organizations worldwide are struggling to find sustainable financial models since the arrival of the internet. Nonprofit radio is no different. Using a thematic analysis of 62 Canadian nonprofit stations’ financial statements from 2012–2015, this ...
Geneviève A Bonin-Labelle +1 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Financement de la chaine de valeurs agricoles : Quel modèle pour la RD Congo ? [PDF]
Mouvements et Enjeux Sociaux, 2023 Dans cet article, il est question de proposer un modèle susceptible de permettre un financement adéquat aux entreprises privées comme étatiques en ce qui concerne le développement de la chaine de valeur des produits agricoles pour lesquels nous avons ...
Paul GIBO LUTANGO
doaj
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source