Results 51 to 60 of about 4,520 (218)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Forecasting Risk Matrices with Economic Policy Uncertainty and Financial Stress: A Machine Learning Approach

Mathematics
Accurately forecasting the risk matrix and constructing a well-controlled portfolio based on these forecasts is the core objective of effective asset allocation. This paper takes the Chinese stock market as the research object, employing multiple machine
Jinda Du, Wenyi Cao, Ziyou Wang
doaj   +1 more source

Leading Indicators of Financial Stress: New Evidence [PDF]

SSRN Electronic Journal, 2015
This paper examines which variables have predictive power for financial stress in 25 OECD countries,using a recently constructed financial stress index (FSI). First, we employ Bayesian model averaging to identify leading indicators of stress. Next, we use those indicators as explanatory variables in a panel model for all countries and in models at the ...
Vasicek, Borek, Zigraiova, Diana, Hoeberichts, Marco, Vermeulen, R., Smidkova, Katerina, de Haan, Jakob   +5 more
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Glycemic control and association with diabetes-related distress, self-management behavior, financial toxicity, and cost-related non-adherence: a mixed-methods study

Frontiers in Endocrinology
BackgroundThe prevalence of diabetes is a growing global health concern. Currently, Nigeria has the highest burden of diabetes in sub-Saharan Africa, and this burden is projected to increase by over 100% by 2050.
Abdulfatai Olamilekan Babaita, Iyabo Yewande Ademuyiwa, Michiko Moriyama   +2 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The Effect of Financial Literacy, Social Support, and Financial Stress on Single-Mother Financial Well-being

Khazanah Sosial
The increasing rates of divorce and the growing number of female-headed households highlight important social dynamics that require serious attention. However, in 2023, only 60.31% of female heads of households were employed, creating economic challenges
Siti Sekar Ayu Fadillah, Irni Rahmayani Johan, Tin Herawati   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Examining the emotional impact and financial strain on caregivers of those with Duchenne muscular dystrophy in Saudi Arabia: findings from a questionnaire-based cross-sectional study

Frontiers in Psychology
BackgroundDuchenne muscular dystrophy (DMD) is a severe, progressive, and life-limiting neuromuscular disorder that imposes a substantial economic burden on healthcare systems and families.
Yazed Alruthia, Yazed Alruthia, Azzam Alobaysi, Horiyah Alhajri, Ghadah Almuaythir, Hala H. Alrasheed, Lama Mohammed Alqarni, Ahmed Khamis Bamaga   +7 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source