Results 71 to 80 of about 529,949 (323)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

PARAMETER EFFICIENT FINE-TUNING AND OVERFITTING IN GPT LARGE LANGUAGE MODELS: A METRIC-BASED COMPARISON

Електроніка та інформаційні технології
Background. Building upon previous research, this study conducts an exploration into Large Language Models (LLMs), with an emphasis on the fine-tuning and assessment of LLaMA-3.1 for instructional tasks. LLaMA-3.1, which is a new generation model and has
Bohdan Pavlyshenko, Ivan Bulka
doaj   +1 more source

Bayesian analysis and naturalness of (Next-to-)Minimal Supersymmetric Models

Journal of High Energy Physics, 2017
The Higgs boson discovery stirred interest in next-to-minimal supersymmetric models, due to the apparent fine-tuning required to accommodate it in minimal theories.
Peter Athron, Csaba Balazs, Benjamin Farmer, Andrew Fowlie, Dylan Harries, Doyoun Kim   +5 more
doaj   +1 more source

GAN-Based Fine-Tuning of Vibrotactile Signals to Render Material Surfaces

IEEE Access, 2020
The design productivity of fine-tuning for vibrotactile stimuli becomes important as consumer devices equipped with vibrotactile actuators will become wide-spread.
Yusuke Ujitoko, Yuki Ban, Koichi Hirota
doaj   +1 more source

SUSY models under siege: LHC constraints and electroweak fine-tuning

, 2014
Recent null results from LHC8 SUSY searches along with the discovery of a SM-like Higgs boson with mass m(h) ~ 125.5 GeV indicates sparticle masses in the TeV range, causing tension with conventional measures of electroweak fine-tuning.
Baer, Howard, Barger, Vernon, Mickelson, Dan, Padeffke-Kirkland, Maren   +3 more
core   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Leveraging Transfer Learning and Mobile-Enabled Convolutional Neural Networks for Improved Arabic Handwritten Character Recognition

IEEE Access
The study explores the integration of transfer learning (TL) with mobile-enabled convolutional neural networks (MbNets) to enhance Arabic Handwritten Character Recognition (AHCR).
Mohsine El Khayati, Ayyad Maafiri, Yassine Himeur, Hamzah Ali Alkhazaleh, Shadi Atalla, Wathiq Mansoor   +5 more
doaj   +1 more source

Research on real-world knowledge mining and knowledge graph completion (IV): construction of a real-world data annotation platform and exploration of automatic extraction method based on pre-trained language models [PDF]

Yixue xinzhi zazhi
Objective To explore the construction of a real-world data annotation platform, and compare the real-world data extraction performance of retrieval augmented generation (RAG) combined with large language models and pre-training fine-tuning methods for ...
YAN Siyu, TAN Jiejun, ZHU Haifeng, HUANG Qiao, WANG Shichun, MA Wenhao, SHI Hanyu, WANG Yongbo, REN Xiangying, HU Wenbin, JIN Yinghui   +10 more
doaj   +1 more source

NMSSM with generalized deflected mirage mediation

, 2019
We propose to generate a realistic soft SUSY breaking spectrum for Next-to-Minimal Supersymmetric Standard Model (NMSSM) with a generalized deflected mirage mediation scenario, in which additional Yukawa and gauge mediation contributions are included to ...
Du, Xiao Kang, Liu, Guo-Li, Wang, Fei, Wang, Wenyu, Yang, Jin Min, Zhang, Yang   +5 more
core   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source