Results 71 to 80 of about 114,061 (302)

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Effect of granular waste compact disc on bond strength between steel bars and surrounding concrete

Fracture and Structural Integrity
In recent decades, researchers have tried to use waste materials as a partial or complete replacement of the gravel ingredients of concrete to reduce environmental impact. One of these materials is electronic waste. The problem of this disposal material,
Barzan Omar Mawlood, Sanaa Ismael Khaleel, Ahmed Heidayet Mohammad   +2 more
doaj   +1 more source

Compressive Strength of Concrete with Malang Sand as Fine Aggregate Substitute

PRESUNIVE CIVIL ENGINEERING JOURNAL
<p class="Abstract">Malang sand has small and rough grains with a sharp surface, it can easily absorb water and adhere to cement. It is very suitable for use as fine aggregate in concrete to improve the quality and durability of concrete. As sand from a volcano, Malang sand has similar characteristics to sand from cold lava resulting from ...
Muhammad Iqbal Paramatatya Satyawan Santoso, Ika Bali   +1 more
openaire   +1 more source

Characterisation of recycled ceramic mortars for use in prefabricated beam-filling pieces in structural floors [PDF]

, 2019
This study analyses a procedure to manufacture mortars with different percentages of ceramic waste as partial replacement for aggregates. The study also examines the physical, chemical and mechanical properties of the new mortars, analysing substitution ...
Morales Conde, María Jesús, Pedreño-Rojas, M. Alejandro, Pérez Gálvez, Filomena, Rubio de Hita, Paloma   +3 more
core   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Mechanical Properties of High Strength Self Compacting Concrete Based on Rheological Mix Proportioning

Civil and Environmental Engineering, 2023
The main problem is to raise the standard of construction, rethinking concrete's expanding potential as a construction material. The scarcity of river sand as a fine aggregate ingredient is currently a widespread issue for many concrete plants.
Narayana Rao U. V., Naga Satish Kumar Ch.   +1 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Influence of limestone waste as partial replacement material for sand and marble powder in concrete properties

HBRC Journal, 2012
Green concrete are generally composed of recycling materials as hundred or partial percent substitutes for aggregate, cement, and admixture in concrete. Limestone waste is obtained as a by-product during the production of aggregates through the crushing ...
Omar M. Omar, Ghada D. Abd Elhameed, Mohamed A. Sherif, Hassan A. Mohamadien   +3 more
doaj   +1 more source

Developmental research of sustainable technologies to minimise problematic road embankment settlements [PDF]

, 2017
Challenging, problematic and non-uniform ground conditions are a night mare to geotechnical engineers tasked with the design and construction of buildings and transport infrastructure. These often suffer undesirable structural settlements.
Abu Talib, M. K., Bakar, I., Ismail, T. N. H. T., Ratha, N., Siang, A. J. L. M., Wijeyesekera, D. C., Zainorabidin, A.   +6 more
core   +1 more source