Results 71 to 80 of about 164,085 (277)
Constructing a concept of number [PDF]
, 2018 Numbers are concepts whose content, structure, and organization are influenced by the material forms used to represent and manipulate them. Indeed, as argued here, it is the inclusion of multiple forms (distributed objects, fingers, single- and two ...
Overmann, Karenleigh
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
A hand full of numbers: a role for offloading in arithmetics learning?
Frontiers in Psychology, 2011 Finger counting has been associated to arithmetic learning in children. We examined children with (n = 14) and without (n = 84) mathematics learning difficulties with ages between 8 to 11 years.
Annelise Júlio Costa +13 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
The co-evolution of number concepts and counting words [PDF]
, 2009 Humans possess a number concept that differs from its predecessors in animal cognition in two crucial respects: (1) it is based on a numerical sequence whose elements are not confined to quantitative contexts, but can indicate cardinal/quantitative as ...
Wiese, Heike
core
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
The body in Renaissance arithmetic: from mnemonics to embodied cognition [PDF]
, 2010 In Medieval and Renaissance arithmetic we find several instances of references to body parts or actions involving body parts. In this paper we will address the question on the historical functions of body parts in mathematics and discuss its relation to ...
Heeffer, Albrecht
core
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Discovery of 16.6 and 25.5 s Pulsations from the Small Magellanic Cloud [PDF]
, 2001 We report the serendipitous detection of two previously unreported pulsars from the direction of the Small Magellanic Cloud, with periods of 16.6 and 25.5 seconds. The detections are based on archival PCA data from the Rossi X-ray Timing Explorer (RXTE).
Bildsten +12 more
core +3 more sources
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source