Results 71 to 80 of about 35,346 (262)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
A Deep Neural Network for Finger Counting and Numerosity Estimation [PDF]
, 2020 In this paper, we present neuro-robotics models with a deep artificial neural network capable of generating finger counting positions and number estimation.
Pecyna, Leszek +2 more
core +1 more source
Considering digits in a current model of numerical development
Frontiers in Human Neuroscience, 2015 Numerical cognition has long been considered the perfect example of abstract information processing. Nevertheless, there is accumulating evidence in recent years suggesting that the representation of number magnitude may not be entirely abstract but ...
Stephanie eRoesch +2 more
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Principal component of finger ridge-counts: their universality
Annals of Human Biology, 1992 A principal component analysis was carried out on radial and ulnar finger ridge-count data on a sample of fishermen of the sea coast of Puri in the state of Orissa in India. The component structure is very similar to that obtained earlier by Roberts and Coope for some English populations, by Arrieta and Lostao for a Basque population, by Siervogel et ...
T, Krishnan, B M, Reddy
openaire +2 more sources
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
The role of fingers in the development of counting and arithmetic skills
Acta Psychologica, 2015 Interactions between fingers and numbers have been reported in the existing literature on numerical cognition. The aim of the present research was to test whether hand interference movements might have an impact on children performance in counting and basic arithmetic problem solving.
Virginie, Crollen, Marie-Pascale, Noël
openaire +2 more sources
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source