Results 161 to 170 of about 130,877 (309)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Estimation of Optical Properties in Postharvest and Processing Technology [PDF]
, 2011 Baranyai, László
core +2 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
INFLUENCE OF ROOTSTOCKS AND STORAGE CONDITIONS ON THE QUALITY OF SWEET CHERRY FRUITS ‘REGINA’
Acta Scientiarum Polonorum: Hortorum Cultus, 2016 Rootstock modifies many fruits features during growth and cropping trees in the orchard. Studies were undertaken to prove the effect of rootstock on the quality of sweet cherry ‘Regina’ fruit before and after storage period.
Ewa Dziedzic +2 more
doaj
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
QUALITY FEATURES OF PARTHENOCARPIC PEARS COLLECTED FROM TREES GROWN ON DIFFERENT ROOTSTOCKS
Acta Scientiarum Polonorum: Hortorum Cultus, 2015 In countries where spring frost frequently causes damage to pear flowers, cropping is possible through natural and induced parthenocarpy. The tendency to bear parthenocarpic fruit is a genetic feature so it differs between cultivars.
Grzegorz P. Łysiak, Wojciech Antkowiak
doaj
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Acta Scientiarum Polonorum: Hortorum Cultus, 2015 The role of pre-harvest aminoethoxyvinylglycine (AVG) treatments on bioac-tive compounds, fruit ripening and quality of Japanese plum fruits (Prunus salicina Lin-dell cv. ‘Fortune’) were investigated in this study.
Emine Kucuker +3 more
doaj