Results 121 to 130 of about 16,184,258 (301)

Screening first-degree relatives of patients with Chronic Kidney Disease (CKD) in Pakistan

Journal of the Pakistan Medical Association
Dear Sir / Madam Chronic Kidney Disease (CKD) poses a worldwide health concern, affecting more than eight hundred million people globally, with underdeveloped nations sharing the greatest disease burden.1 It’s hypothesised that by 2030, countries with
Amna Ilyas, Bakhtawar Ali
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Gastric mucosa alterations in first-degree relatives of gastric cancer patients

, 2005
First-degree relatives of gastric cancer patients have an increased risk of developing such neoplasia, and several alterations in gastric mucosa of these subjects have been described.
I. Sarcina, E. Ierardi, IERARDI, ENZO GIANNI, VECCHIONE, Aldo, A. ROMITI, ROMITI, ADRIANA, C. Hassan, TOMAO, SILVERIO, A. Zullo, V. De Francesco, Romiti, Anita, TOMAO, FEDERICA, S. TOMAO, Hassan, Cesare, S. Morini, A. VECCHIONE   +15 more
core  

Increased risk of essential tremor in first-degree relatives of patients with Parkinson's disease.

, 2007
International audienceWe conducted a historical cohort study of 981 first-degree relatives of 162 patients with Parkinson's disease (PD) and of 838 first-degree relatives of 147 controls representative of the population of Olmsted County, Minnesota.
Ahlskog, J. Eric, Grossardt, Brandon, R., Bower, James, H., Elbaz, Alexis, Mcdonnell, Shannon, K., Schaid, Daniel, J., Maraganore, Demetrius, M., Rocca, Walter, A., Maraganore, Demetrius,, Walter A. Rocca, Daniel J. Schaid, James H. Bower, J. Eric Ahlskog, Mcdonnell, Shannon,, Bower, James,, Rocca, Walter,, Brandon R. Grossardt, Schaid, Daniel,, Demetrius M. Maraganore, Alexis Elbaz, Shannon K. McDonnell, Grossardt, Brandon,   +21 more
core   +1 more source

Cardiovascular risk and subclinical atherosclerosis in first-degree relatives of patients with premature cardiovascular disease

American Journal of Preventive Cardiology
Background: Screening first-degree relatives (FDRs) of patients with premature coronary artery disease (CAD) is recommended but not routinely performed.
Diana N. Vikulova, Danielle Pinheiro-Muller, Gordon Francis, Frank Halperin, Tara Sedlak, Keith Walley, Christopher Fordyce, GB John Mancini, Simon N. Pimstone, Liam R. Brunham   +9 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Intestinal permeability in patients with Crohn's disease and ulcerative colitis and their first degree relatives

, 1994
Increased intestinal permeability in patients with Crohn's disease and their first degree relatives has been proposed as an aetiological factor. The nine hour overnight urinary excretion of polyethyleneglycol-400 (PEG-400) and three inert sugars ...
Hollander, D, Katz, K D, Orholm, M, Munkholm, P, Langholz, E, Binder, V, Thornberg, K   +6 more
core   +1 more source