Results 111 to 120 of about 26,268,552 (306)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

National Treatment Purchase Fund annual report 2004.

, 2004
The mission of the National Treatment Purchase Fund is to reduce the length of time public patients are on hospital waiting lists by offering them a choice in obtaining access to treatment quickly, safely and to a high standard of patient satisfaction ...
National Treatment Purchase Fund
core  

First-line therapies in inflammatory bowel disease [PDF]

, 2012
BACKGROUND AND AIMS: Medical therapy of inflammatory bowel disease (IBD) is becoming more complex, given the increasing choice of drugs to treat Crohn's disease (CD) and ulcerative colitis (UC). We aimed to summarize the current guidelines for first-line
Safroneeva, Ekaterina, Rogler, Gerhard, Alain M. Schoepfer, Manz, Michael, Mottet, Christian, Roger Wanner, Ekaterina Safroneeva, Gerhard Rogler, Pascal Frei, Frei, Pascal, Luc Biedermann, Michael Manz, Christian Mottet, Christine Manser, Girardin, Marc, Manser, Christine, Wanner, Roger, Marc Girardin, Biedermann, Luc, Schoepfer, Alain M, Safroneeva, E., Manz, M., Manser, C., Manz M, Girardin, M., Biedermann L, Mottet C, Rogler, G., Rogler G, Schoepfer AM, Girardin M, Mottet, C., Wanner, R., Biedermann, L., Safroneeva E, Frei P, Frei, P., Schoepfer, A.M., Manser C, Wanner R   +39 more
core   +2 more sources

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

European standard clinical practice recommendations for newly diagnosed ependymoma of childhood and adolescence

EJC Paediatric Oncology
Ependymomas are tumors of glial origin representing the second most common malignant brain tumors of childhood. Peak incidence in childhood is under 3 years of age.
Alba Rubio-San-Simón, Timothy A. Ritzmann, Denise Obrecht-Sturm, Martin Benesch, Beate Timmermann, Pierre Leblond, John-Paul Kilday, Geraldina Poggi, Nicola Thorp, Maura Massimino, Marie-Lise van Veelen, Martin Schuhmann, Ulrich-Wilhelm Thomale, Stephan Tippelt, Ulrich Schüller, Stefan Rutkowski, Richard G. Grundy, Stephanie Bolle, Ana Fernández-Teijeiro, Kristian W. Pajtler   +19 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

First line treatment in hypertension.

BMJ, 1991
L E Ramsay, W W Yeo
  +7 more sources

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Role of rituximab in first-line treatment of chronic lymphocytic leukemia

Therapeutics and Clinical Risk Management, 2010
Jeffrey Bryan, Gautam BorthakurDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USAAbstract: Chronic lymphocytic leukemia (CLL) is a biologically heterogeneous illness that primarily afflicts the elderly.
Jeffrey Bryan, Gautam Borthakur
doaj  

Trabectedin may be a valuable treatment option for elderly patients with metastatic soft tissue sarcomas

Frontiers in Oncology
BackgroundIn the landscape of metastatic soft tissue sarcoma (mSTS) treatment, anthracyclines have shown efficacy; however, their associated toxicity imposes significant limitations, especially in frail elderly patients with mSTS who are highly ...
Gianmaria Miolo, Angela Buonadonna, Davide Lombardi, Simona Scalone, Andrea Lauretta, Lara Della Puppa, Giuseppe Corona   +6 more
doaj   +1 more source