Results 91 to 100 of about 26,268,552 (306)

The efficacy of antimalarial monotherapies, sulphadoxine-pyrimethamine and amodiaquine in East Africa: implications for sub-regional policy. [PDF]

, 2003
Between 1998 and 2001, Kenya, Uganda, Tanzania, Zanzibar, Rwanda and Burundi changed antimalarial drug policy, in the face of widespread chloroquine resistance.
East African Network for Monitoring Antimalarial Treatment (EANMAT), East African Network for Monitoring Antimalarial Treatment (EANM   +1 more
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

First-line treatment of advanced ALK-positive non-small-cell lung cancer

, 2015
Shipra Gandhi,1 Hongbin Chen,2 Yujie Zhao,2 Grace K Dy2 1Department of Internal Medicine, State University of New York, 2Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA Abstract: Non-small-cell lung cancer (NSCLC) is one of the ...
Gandhi S, Dy GK, Chen H, Zhao Y
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

First-line treatment for hypertension [PDF]

European Heart Journal, 2002
P R, Jackson, L E, Ramsay
openaire   +2 more sources

Toxicity associated with stavudine dose reduction from 40 to 30 mg in first-line antiretroviral therapy. [PDF]

, 2011
To compare the incidence and timing of toxicity associated with the use of a reduced dose of stavudine from 40 to 30 mg in first-line antiretroviral therapy (ART) for HIV treatment and to investigate associated risk ...
Etard, JF, Pinoges Loretxu, Pujades-Rodriguez, M., Etard Jean-François, Pujades-Rodríguez, M, Jean-François Etard, Pinoges, Loretxu, Szumilin Elisabeth, Dantony, E, AIDS Working Group of Médecins Sans Frontières, Szumilin, E, Etard, Jean-François, Szumilin, Elisabeth, Ecochard, R, René Ecochard, Dantony Emmanuelle, Pinoges, L., Dantony, Emmanuelle, Ecochard René, Carrillo-Casas, Esther, Pinoges, L, Ecochard, René, Elisabeth Szumilin, Carrillo-Casas, E, Carrillo-Casas Esther, Esther Carrillo-Casas, Emmanuelle Dantony, Pujades-Rodríguez Mar, Etard, J.F., Carillo-Casa, E., Loretxu Pinoges, Szumilin, E., Mar Pujades-Rodríguez, Carrillo-Casas, E., Pujades-Rodríguez, Mar, Ecochard, R., Dantony, E.   +36 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

A Multicenter Retrospective Study: Impact of First-Line Treatment Strategies on second-Line Efficacy and Safety of Regorafenib with or Without PD-1 Inhibitors in Unresectable Hepatocellular Carcinoma

Journal of Hepatocellular Carcinoma
Weihong Ma,1,2,* Yinyin Li,1,* Yinying Lu,1,2 Zhipeng Liang,3 Hongli Yu,1,2 Jie Han,1,2 Jiaqi Liu,1,2 Wenjing Wang,1,2 Caiyun Peng,1 Jiamin Cheng1 1Senior Department of Hepatology, The 5th Medical Center of the PLA General Hospital ...
Ma W, Li Y, Lu Y, Liang Z, Yu H, Han J, Liu J, Wang W, Peng C, Cheng J   +9 more
doaj  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

High efficacy and low toxicity of weekly docetaxel given as first-line treatment for metastatic breast cancer [PDF]

, 2005
Background: Docetaxel is one of the most effective antitumor agents currently available for the treatment of metastatic breast cancer (MBC). This phase II multicenter study prospectively analyzed the efficacy and toxicity of docetaxel given on a weekly ...
Abenhardt, Wolfgang, Leinung, S., V. Heinemann, Stemmler, J., W. Mair, Jackisch, C., O. Brudler, G. Deutsch, Stamp, J., Dorn, B., J. Stemmler, Brudler, O., Stauch, M., M. Malekmohammadi, Papke, J., M. Stauch, Deutsch, G., Vehling-Kaiser, U., S. Leinung, B. Dorn, Heinemann, Volker, C. Jackisch, U. Vehling-Kaiser, Mair, W., Kentenich, C., J. Papke, C. Kentenich, Malekmohammadi, M., W. Abenhardt, J. Stamp   +29 more
core   +1 more source