Results 71 to 80 of about 26,268,552 (306)

Responders to first-line osteoarthritis treatment had reduced frequency of hip and knee joint replacements within 5 years: an observational register-based study of 44,311 patients

Acta Orthopaedica
Background and purpose: First-line treatment (education, exercise) for patients with hip and knee osteoarthritis (OA) aims to reduce pain and improve function.
Kristin Gustafsson, Anna Cronström, Ola Rolfson, Eva Ageberg, Therese Jönsson   +4 more
doaj   +1 more source

Frequency of first- and second-line treatment.

, 2019
Frequency of first- and second-line treatment.
Thirupathi Pattipaka (6175754), Yulin Li (36434), Adrian Cassidy (6175760), Apar Kishor Ganti (6175763), Anita Appius (6175751), Andrea Feyereislova (6175757)   +5 more
core   +1 more source

The Impact of Tenapanor on Body Composition and Blood Pressure in Peritoneal Dialysis Patients: A Pilot Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Instruction Tenapanor potentially affects fluid volume and blood pressure. This study explored its effects on these parameters in patients undergoing peritoneal dialysis (PD). Methods We conducted a single‐arm, prospective observational study that enrolled 10 patients on PD with hyperphosphatemia who were newly initiated on tenapanor.
Shun Yoshida, Kengo Asahina, Keiichi Osano, Natsumi Saegusa, Kohei Yamamura, Kie Ohkoshi, Miho Shikata, Toshihisa Ishii, Makiko Konishi, Kazuya Takahashi, Kohei Uchimura, Ayumu Nakashima   +11 more
wiley   +1 more source

Surgery should be the first line of treatment for empyema [PDF]

Respirology, 2010
ABSTRACTFew thoracic conditions present such considerable challenges as pleural space infections, herein termed ‘empyema’ as a general term. Patients may present with free‐flowing infected pleural effusions that readily drain by catheter or, at the other extreme, with organized intrapleural collections of pus with thick pleural peels that require open ...
Ioannis E, Petrakis, John E, Heffner, Jeffrey S, Klein   +2 more
openaire   +2 more sources

First Line CombinAtion Therapy in the Treatment of Stage II and III Hypertension (FLASH). [PDF]

, 2020
Background: Lowering blood pressure (BP) leads to reduced risk of stroke, myocardial infarction, and cardiovascular mortality. Single-pill combination therapies may deliver better BP control than increasing the dose of monotherapies or using more drugs ...
Burnier, Michel, Spirk, D., Noll, S., Noll, Sarah, Sudano, I., Rimoldi, Stefano, Noll, Georg, Sudano, Isabella, Burnier, M., Spirk, David, Noll, G., Rimoldi, S., Noll G, Sudano I, Spirk D, Rimoldi S, Burnier M, Noll S   +17 more
core   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Optimal first-line treatment in ovarian cancer

Annals of Oncology, 2012
Treatment of ovarian cancer remains challenging despite the high complete response rate seen after maximal surgical debulking surgery and platinum-combination chemotherapy. as most patients will relapse and eventually succumb to ovarian cancer, new strategies are urgently required to improve survival.
F A, Raja, N, Chopra, J A, Ledermann
openaire   +2 more sources

Percent of individuals starting partially inactive second-line treatment due to acquired drug resistance during first-line treatment.

, 2012
Percent of individuals starting partially inactive second-line treatment due to acquired drug resistance during first-line treatment.
Valentina Cambiano (146513), Deenan Pillay (7888), Silvia Bertagnolio (57174), Michael R. Jordan (146520), Andrew N. Phillips (146556), Alec Miners (146534), Jens Lundgren (146550), Viktor von Wyl (146506)   +7 more
core   +1 more source

Clinical Outcomes with First-line Endocrine Therapy or Chemotherapy in Postmenopausal HR+/HER2- Metastatic Breast Cancer [PDF]

, 2015
Objective To describe patient profiles and clinical outcomes associated with first-line endocrine monotherapy (ET) and chemotherapy (CT) for postmenopausal HR+/HER2– metastatic breast cancer (mBC) patients. Methods This is a retrospective chart review of
Yanni Hao, Alexander R. Macalalad, Eric Q. Wu, Yan Song, James E. Signorovitch, Peggy L. Lin   +5 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source