Results 81 to 90 of about 26,268,552 (306)

First-line treatment of chronic myeloid leukemia with nilotinib: critical evaluation

Journal of Blood Medicine, 2012
Pier Paolo Piccaluga,* Stefania Paolini,* Clara Bertuzzi, Antonio De Leo, Gianantonio RostiHematopathology and Hematology Sections, Department of Hematology and Oncological Sciences, "L and A Seràgnoli", S Orsola-Malpighi ...
Piccaluga PP, Paolini S, Bertuzzi C, De Leo A, Rosti G   +4 more
doaj  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Efficacy and safety of triplet regimen capecitabine, oxaliplatin, and irinotecan (XELOXIRI) as first-line chemotherapy for advanced pancreatic cancer

BMC Cancer
Background The 5-fuorouracil, oxaliplatin and irinotecan (FOLFOXIRI) regimen is the standard first-line treatment for advanced pancreatic cancer (APC).
Bi-Yang Cao, Qi Cao, Xiao-Ting Ma, Kai Ou, Wen-Wei Yang, Le-Tian Zhang, Jing-Yu Lu, Zhi-Chao Jiang, Wen Zhang, Jie Zhang, Qi Wang, Li-Zhen Gao, Lin Yang   +12 more
doaj   +1 more source

Prolonged survival of patients receiving trastuzumab beyond disease progression for HER2 overexpressing metastatic breast cancer (MBC) [PDF]

, 2005
Background: The aim of this retrospective analysis was to evaluate the impact of trastuzumab-based regimens on the survival of patients with HER2-overexpressing metastatic breast cancer (MBC).
Heinrich, B., Stemmler, H. J., Kahlert, S., Heinemann, Volker, Siekiera, W., Untch, M.   +5 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

First-Line Treatment with Tiotropium/Olodaterol Improves Physical Activity in Patients with Treatment-Naïve Chronic Obstructive Pulmonary Disease

International Journal of COPD, 2020
Koichiro Takahashi,1 Masaru Uchida,2 Go Kato,3 Ayako Takamori,4 Takashi Kinoshita,5 Makoto Yoshida,6 Ryo Tajiri,4 Keisuke Kojima,7 Hiroshi Inoue,8 Hiromi Kobayashi,9 Hironori Sadamatsu,1 Hiroki Tashiro,1 Masahide Tanaka,1 Shinichiro Hayashi,10 Atsushi ...
Takahashi K, Uchida M, Kato G, Takamori A, Kinoshita T, Yoshida M, Tajiri R, Kojima K, Inoue H, Kobayashi H, Sadamatsu H, Tashiro H, Tanaka M, Hayashi S, Kawaguchi A, Kimura S, Sueoka-Aragane N, Kawayama T   +17 more
doaj  

Biological Therapeutic Advances for the Treatment of Advanced Urothelial Cancers

Biologics: Targets & Therapy, 2021
Mimma Rizzo,1 Patrizia Giannatempo,2 Camillo Porta1,3 1Division of Medical Oncology, A.O.U. Consorziale Policlinico di Bari, Bari, Italy; 2Department of Medical Oncology, Fondazione I.R.C.C.S.
Rizzo M, Giannatempo P, Porta C
doaj  

Waterfall plot of treatment-free interval following first-line therapy.

, 2020
Waterfall plot of treatment-free interval following first-line therapy.
Toby A. Eyre (8479401), Grant Vallance (6078815), Susan McLain-Smith (8479398), Sally Moore (6078818), Faye A. Sharpley (8479395), Jaimal Kothari (6078821), Karthik Ramasamy (795392), Faouzi Djebbari (6004379)   +7 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Adaptive guidelines to inform first-line treatment recommendations for gonorrhea.

, 2020
Adaptive guidelines to inform first-line treatment recommendations for gonorrhea.
Reza Yaesoubi (207900), Joshua A. Salomon (8668311), Harrell Chesson (8668308), Thomas L. Gift (8668305), Katherine Hsu (8668302), Yonatan H. Grad (3123549), Ted Cohen (118302)   +6 more
core   +1 more source