Results 21 to 30 of about 26,268,552 (306)

Role of gemcitabine in the treatment of advanced and metastatic breast cancer [PDF]

, 2003
Gemcitabine is an antimetabolite drug with proven antitumor activity and tolerability in metastatic breast cancer. In a total of nine studies, gemcitabine monotherapy has reached response rates of up to 37% in the first-line setting, 26% in the second ...
Heinemann, Volker
core   +1 more source

Immunological failure of first-line and switch to second-line antiretroviral therapy among HIV-infected persons in Tanzania: analysis of routinely collected national data. [PDF]

, 2015
OBJECTIVES: Rates of first-line treatment failure and switches to second-line therapy are key indicators for national HIV programmes. We assessed immunological treatment failure defined by WHO criteria in the Tanzanian national HIV programme. METHODS: We
Ramadhani, Angela, Vanobberghen, Fiona M, Mmbando, Donan, Wringe, Alison, Todd, Jim, Zaba, Basia, Kilama, Bonita   +6 more
core   +1 more source

Ibrutinib and Venetoclax for First-Line Treatment of CLL

New England Journal of Medicine, 2019
Ibrutinib, an inhibitor of Bruton's tyrosine kinase, and venetoclax, an inhibitor of B-cell lymphoma 2 protein, have been approved for patients with chronic lymphocytic leukemia (CLL). Preclinical investigations have indicated potential synergistic interaction of their combination.We conducted an investigator-initiated phase 2 study of combined ...
Kater, Arnon P., Levin, Mark David, Niemann, Carsten U.   +2 more
openaire   +7 more sources

First- and Second-Line Palliative Systemic Treatment Outcomes in a Real-World Metastatic Pancreatic Cancer Cohort

, 2022
Background: Metastatic pancreatic ductal adenocarcinoma (PDAC) is characterized by a poor survival rate, which can be improved by systemic treatment. Consensus on the most optimal first- and second-line palliative systemic treatment is lacking.
Creemers, G.J., Creemers, Geert-Jan, Besselink, M.G., Besselink, Marc G., Wilmink, Johanna W., Mohammad, N.H., Dijksterhuis, Willemieke P.M., Dijksterhuis, W.P.M., Wilmink, J.W., Creemers, Geert Jan, Dijksterhuis, Willemieke P. M., van Laarhoven, Hanneke W. M., Pijnappel, E.N., de Vos-Geelen, J., van Laarhoven, Hanneke W.M., Homs, Marjolein Y. V., de Vos-Geelen, Judith, de Groot, J.W.B., de Groot, Jan Willem B., van der Geest, Lydia G., Mohammad, Nadia Haj, van der Geest, L.G., van Laarhoven, H.W.M., Homs, Marjolein Y.V., Homs, M.Y.V., Pijnappel, Esther N.   +25 more
core   +1 more source

Real-world Treatment Patterns and Overall Survival in Locally Advanced and Metastatic Urothelial Tract Cancer Patients Treated with Chemotherapy in Denmark in the Preimmunotherapy Era: A Nationwide, Population-based Study

European Urology Open Science, 2021
Background: Real-world treatment patterns and survival outcomes of locally advanced, unresectable, and metastatic urinary tract cancer (mUTC) patients have not previously been studied in a nationwide, population-based cohort.
Lise H. Omland, Henriette Lindberg, Andreas Carus, Anne Birgitte Als, Niels Viggo Jensen, Gry A. Taarnhøj, Redas Trepiakas, Charlotte Suetta, Lars H. Omland, Helle Pappot   +9 more
doaj   +1 more source

European Registry on Helicobacter pylori Management: Effectiveness of First and Second-Line Treatment in Spain

Antibiotics, 2020
The management of Helicobacter pylori infection has to rely on previous local effectiveness due to the geographical variability of antibiotic resistance. The aim of this study was to evaluate the effectiveness of first and second-line H. pylori treatment
María Caldas, Ángeles Pérez-Aisa, Manuel Castro-Fernández, Luis Bujanda, Alfredo J. Lucendo, Luis Rodrigo, Jose M. Huguet, Jorge Pérez-Lasala, Javier Molina-Infante, Jesús Barrio, Luis Fernández-Salazar, Ángel Lanas, Mónica Perona, Manuel Domínguez-Cajal, Juan Ortuño, Blas José Gómez-Rodríguez, Pedro Almela, Josep María Botargués, Óscar Núñez, Inés Modolell, Judith Gómez, Rafael Ruiz-Zorrilla, Cristóbal De la Coba, Alain Huerta, Eduardo Iyo, Liliana Pozzati, Rosario Antón, Mercé Barenys, Teresa Angueira, Miguel Fernández-Bermejo, Ana Campillo, Javier Alcedo, Ramón Pajares-Villaroya, Marianela Mego, Fernando Bermejo, José Luis Dominguez-Jiménez, Llúcia Titó, Nuria Fernández, Manuel Pabón-Carrasco, Ángel Cosme, Pilar Mata-Romero, Noelia Alcaide, Inés Ariño, Tommaso Di Maira, Ana Garre, Ignasi Puig, Olga P. Nyssen, Francis Megraud, Colm O’Morain, Javier P. Gisbert   +49 more
doaj   +1 more source

Steroids: First Line Treatment in Pediatrics

Canadian Respiratory Journal, 1995
The benefits derived from the use or inhaled steroids in pediatric asthma are reviewed in relation to the age of the patient, the delivery system and the compliance versus frequency of administration of these medications.
Sheldon Spier
doaj   +1 more source

Follicular lymphoma: first - line selection criteria of treatment [PDF]

Терапевтический архив, 2019
Follicular lymphoma (FL) is a tumor that develops from the B cells of the germinal center; characterized by recurrent and remitting course of the disease, the transformation of a tumor into diffuse large B-cell lymphoma (DLBCL) is possible.
E S Nesterova, S K Kravchenko, A M Kovrigina, E G Gemdzhian, L V Plastinina, F E Babaeva, T N Obukhova, A U Magomedova, T V Gaponova, A M Kremenetskaya, A I Vorobyev   +10 more
doaj   +1 more source

Ocoxin as a complement to first line treatments in cancer [PDF]

International Journal of Medical Sciences, 2021
Chemotherapy and radiotherapy are the most frequent treatment for patients suffering from malignant progression of cancer. Even though new treatments are now being implemented, administration of these chemotherapeutic agents remains as the first line option in many tumor types. However, the secondary effects of these compounds represent one of the main
Benedicto García, Aitor, Sanz, Eduardo, Márquez Clavijo, Joana   +2 more
openaire   +3 more sources

First-Line Treatment in Hypertension [PDF]

Drugs, 1990
Once-daily administration of perindopril 4mg has been compared with captopril 25mg twice daily, atenolol 50mg once daily or a combination of hydrochlorothiazide 50mg plus amiloride 5mg once daily in double-blind studies of patients with supine diastolic blood pressures between 95 and 125mm Hg.
openaire   +4 more sources