Results 221 to 230 of about 17,850,316 (257)

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Autoantibody screening in children who are first-degree relatives of individuals with type 1 diabetes in a sibling-dominant cohort in Turkey: a multicentre study on prevalence, determinants and post-screening parent-child anxiety. [PDF]

Diabetologia
Yılmaz UC, Kızılay DÖ, Kurt ÖK, Balaban Berber İB, Gökdemir İ, Ata A, Erden D, Basa EG, Yalçın ÖF, Onguner S, Balkı HG, Çetin SK, Özen S, Demir G, Baş GY, Soylu M, Anık A, Gürbüz F, Demir K, Köprülü Ö, Altıncık SA, Filibeli BE, Özbaran B, Onmuş RD, Gökşen D.   +24 more
europepmc   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Behavioural changes in exposure patterns after genetic counselling among asymptomatic first-degree relatives of patients with pulmonary fibrosis and carriers of a telomere-related gene variant. [PDF]

ERJ Open Res
Sesé L, Bouvry D, Kannengiesser C, Wémeau-Stervinou L, Jouneau S, Prevot G, Vagnarelli S, Guérin C, Lassus A, Crestani B, Bonniaud P, Cottin V, Gueguen S, Nunes H, Borie R.   +14 more
europepmc   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Filled Pause Use in Autistic Adults and Their First-Degree Relatives: Gender Differences and Within-Family Associations. [PDF]

J Speech Lang Hear Res
Friedman L, Maltman N, Sterling A, Hudock RL, DaWalt LS.   +4 more
europepmc   +1 more source

Identification of individuals at high risk of developing rheumatoid arthritis: a balanced random forest model in a cohort of 1544 first-degree relatives. [PDF]

RMD Open
Aymon R, Lamacchia C, Gilbert BTP, Grundhuber M, Gehring I, Swiniarski S, Studer O, Salis Z, Guemara R, Spoerl D, Dudler J, Möller B, Dan D, Brulhart L, Von Mühlenen I, Kyburz D, Rubbert-Roth A, Ciurea A, Mueller R, Courvoisier DS, Finckh A.   +20 more
europepmc   +1 more source

Longitudinal Trajectory of Cognition, Brain Morphometry, and Brain Predicted Age in Unaffected First-Degree Relatives of Patients With Bipolar Disorder. [PDF]

Bipolar Disord
Kjærstad HL, Macoveanu J, Ysbæk-Nielsen AT, Damgaard V, Frangou S, Knudsen GM, Coello K, Stanislaus S, Faurholt-Jepsen M, Vinberg M, Kessing LV, Miskowiak KW.   +11 more
europepmc   +1 more source