Results 51 to 60 of about 60,314 (290)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Preliminary study of factors affecting the superovulatory response of high producing dairy cows superstimulated regardless of the stage of estrous cycle in Egypt

Beni-Suef University Journal of Basic and Applied Sciences, 2014
This work was conducted as a first time commercial production of embryos from lactating Holstein and Brown Swiss cows using multiple ovulation embryo transfer (MOET) technology in Egypt.
M.M. Hussein, R.L. Abdel Aziz, A. Abdel-Wahab, H. El-Said   +3 more
doaj   +1 more source

How Secure is Exponent-blinded RSA–CRT with Sliding Window Exponentiation?

Transactions on Cryptographic Hardware and Embedded Systems, 2023
This paper presents the first security evaluation of exponent-blinded RSA–CRT implementation with sliding window exponentiation against cache attacks. Our main contributions are threefold.
Rei Ueno, Naofumi Homma
doaj   +1 more source

First flush and natural aggregation of particles in highway runoff

Water Science and Technology, 2006
Particle Size Distribution (PSD) in highway runoff was monitored in the 2004–2005 rainy season at three highway sites in west Los Angeles, California. PSD was measured for 200 grab samples for 18 storm events. Particles and especially larger particles showed a strong first flush.
Y, Li, S L, Lau, M, Kayhanian, M K, Stenstrom   +3 more
openaire   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

WHISPER: A Tool for Run-Time Detection of Side-Channel Attacks

IEEE Access, 2020
High resolution and stealthy attacks and their variants such as Flush+Reload, Flush+Flush, Prime+Probe, Spectre and Meltdown have completely exposed the vulnerabilities in Intel's computing architecture over the past few years.
Maria Mushtaq, Jeremy Bricq, Muhammad Khurram Bhatti, Ayaz Akram, Vianney Lapotre, Guy Gogniat, Pascal Benoit   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The first application of flush probe arrays on HL-3 tokamak

Nuclear Materials and Energy
Newly flush-mounted Langmuir probe arrays are fabricated and applied in the HL-3 tokamak to investigate its advanced divertor physics such as snowflake and tripod divertors.
Z.H. Huang, L.W. Yan, K.Y. Yi, Na Wu, W.J. Chen, W.C. Wang, Yu He, J. Chen, J. Cheng, W. Zhao, J.M. Gao, L. Nie, Z.B. Shi, X.Q. Ji, W.L. Zhong   +14 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source