Results 101 to 110 of about 14,782,076 (302)

Targeting the KAT7/H3K14ac/RAC2 Axis Mediates OXPHOS to Promote Stemness Maintenance and Malignancy in Glioblastoma

Advanced Science, EarlyView.
SOX2 upregulates KAT7 in glioma stem cells, where KAT7 deposits H3K14 acetylation at the RAC2 promoter to activate RAC2 transcription. RAC2‐GTP subsequently promotes PAK1/2/3 phosphorylation, increasing tricarboxylic acid cycle flux and mitochondrial respiration to support glioblastoma malignancy.
Jilong Liu, Yanfei Sun, Yuehua Zhu, Guangjing Mu, Jiazheng Wang, Liangliang Wang, Feihu Zhao, Zhimin Zhao, Jian Wang, Ying He, Zheng Jiang, Xingang Li, Mingzhi Han, Bin Huang   +13 more
wiley   +1 more source

Alteration of gene expression in mammary gland tissue of dairy cows in response to dietary unsaturated fatty acids [PDF]

, 2011
The aim of this study was to determine the effects of supplementing unprotected dietary unsaturated fatty acids (UFAs) from different plant oils on gene expression in the mammary gland of grazing dairy cows.
Kruijt, L., Baal, J., van, Mach Casellas, N., Jacobs, A.A.A., Smits, M.A.   +4 more
core   +1 more source

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

SEASON OF DELIVERY, AGE OF FIRST FERTILISATION AND MILKING YIELD DURING THE FIRST LACTATION PERIOD OF HEIFERS

, 2020
{"references": ["Baichev Zh. (1987). Prouchvane na niakoi aspekti na biologiata i patologiata na razmnozhitelnia proces pri parvotelkite v selekcionni fermi. Disertatsia, Sofia. (BG).", "Baichev Zh. (2007). Rolya na meltonina v razmnozhitelnia protses i stresa pri edrite prezhivni. Dis-ertatsia, Sofia. (BG).", "Naglis G. (2019).
Vladimir Plansky, Kalin Hristov
openaire   +1 more source

Heat stress affects the milk yield, milk composition, serum oxidative status, and metabolites of Holstein cows during mid-lactation

, 2023
Seasonal heat stress and metabolic disorders during mid-lactation are the main factors limiting production in Holstein cows, and several proteins and molecules involved in metabolic pathways are altered in response to stress.
Yongqiang Li, Liang Xin, Jianan Dong, Wei Zhao, Tao Wang, Zhe Sun, Xuefeng Zhang, Zhiyi Han, Xue Chen, Yuguo Zhen, Jun Xiao, Guixin Qin   +11 more
core   +1 more source

Spatiotemporally Controlled Sequential Chemo‐Immunotherapy Activates Pyroptosis for Robust Anti‐Tumor Immunotherapy

Advanced Science, EarlyView.
A glutathione and ultrasound dual‐responsive cerasome achieves sequential co‐delivery of gemcitabine and BMS1166 in tumors. Chemotherapy priming followed by on‐demand PD‐L1 blockade synergistically amplifies anti‐tumor immunity, inhibiting primary tumor growth, distant metastasis and inducing durable immune memory.
Suhui Sun, Ruiqi Wu, Qingshuang Tang, Yunli Xu, Wanrui Shi, Mengxin Wang, Haonan Wang, Yan Luo, Cheng Ma, Xiaolong Liang   +9 more
wiley   +1 more source

GENETIC AND PHENOTYPIC CORRELA TIONS FOR SOME ECONOMIC TRAITS IN DAIRY CATTLE

Pakistan Veterinary Journal, 2001
Data on lactation records of 1113 purebred Sahiwal and 784 Holstein Friesian X Sahiwal (FS) and Jersey X Sahiwal (JS) crossbred cows kept at the Livestock Production Research Institute (LPRl), Bahadurnagar, District Okara and Qadirabad District Sahiwal ...
Manzoor Ahmad, J. H. J. van der Werf1 and Khalid laved2
doaj  

Palmitoyl Acyltransferase Zdhhc17 Promotes Functional Recovery After Spinal Cord Injury by Targeting the Nuclear Transport Factors Kpna2 and Ipo9

Advanced Science, EarlyView.
In this study, we demonstrate that Zdhhc17, acting as a PAT, suppresses neuronal apoptosis and promotes axon regeneration after injury, thereby enhancing functional recovery following SCI. In this context, Kpna2 and Ipo9 serve as novel palmitoylation substrates of Zdhhc17, whose palmitoylation prevents the injury‐induced degradation of their proteins ...
Meixuan Chen, Huan Chen, Sining Ding, Fan Liu, Xiaofei Zheng, Yuan Wang, Ruitu Tian, Huan Li, Peilin Liu, Le Hu, Bin Liu, Limin Rong, Mangmang Li   +12 more
wiley   +1 more source

Comparative Study on Milk Production Dynamics and Precocity in Brown Cows of Brown Swiss Type and Romanian Spotted Cows of Fleckvieh Type

Scientific Papers Animal Science and Biotechnologies, 2023
The aim of this study was to assess the milk production dynamics in one dairy farm rearing both Brown and Romanian Spotted breed cows. The study was carried out at the Research and Development Station for Bovine Raising Arad, on 321 lactations obtained ...
Ludovic-Toma Cziszter, Radu Ionel Neamț, Florin Cristian Neciu, Daniela Elena Ilie, Silvia Erina, Liviu Ioan Costin, Florin Cornel Marinescu, Simona Baul   +7 more
doaj  

Genetic parameters of 305 days and monthly test-day milk yields in Murrah buffaloes

Indian Journal of Animal Sciences, 2016
The present investigation was carried out using first lactation 9,071 monthly test-day milk yield records of 965 Murrah buffaloes that calved from 1977 to 2012 sired by 98 bulls maintained at ICAR-National Dairy Research Institute, Karnal.
MANVENDRA SINGH, AVTAR SINGH, A K GUPTA, S K DASH, P R SHIVAHRE, SAROJ KU SAHOO, G S AMBHORE   +6 more
doaj   +1 more source