Results 101 to 110 of about 3,056,976 (349)
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Simplices in large sets and directional expansion in ergodic actions
Forum of Mathematics, SigmaIn this paper, we study ergodic $\mathbb {Z}^r$ -actions and investigate expansion properties along cyclic subgroups. We show that under some spectral conditions, there are always directions which expand significantly a given measurable set with ...
Michael Björklund, Alexander Fish
doaj +1 more source
Correction to: Effect of rice straw extracts on growth of two phytoplankton isolated from a fish pond [PDF]
, 2019 Hamed Eladel +4 more
openalex +1 more source
A natural cure for the pet fish problem: feature emergence as classificatory composition [PDF]
, 2013 Where do emergent features come from? This has long been an intriging puzzle. The concept of pet fish illustrates the difficulty. Most people expect pet fish to live in bowls, even though this is not something either pets or fish normally do.
Thornton, Chris
core +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Multiple scales of biological variability in New Zealand streams : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Ecology at Massey University, Manawatū, New Zealand [PDF]
, 2016 Stream fish communities in Taranaki, New Zealand, were studied for the patterns and drivers of their spatial ecology. The study was focused on three main themes: a) complementarity between geography and landuse in driving regional distribution patterns ...
Jayasuriya
core
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Eden Fisheries Advisory Committee 29th April, 1975 [PDF]
, 1975 This is the report from the Eden Fisheries Advisory Committee meeting, which was held on the 29th April, 1975. It covers information on fishery byelaws, and a report by unit fisheries officer on fisheries activities.
core
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source