Results 61 to 70 of about 229,943 (264)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Evaluation of the Effectiveness of a Matrix of Exogenous Proteases in the Nutrition of Shrimp Penaeus vannamei

Animals
This study evaluated the effectiveness of a matrix of acid and alkaline proteases in diets for Penaeus vannamei shrimp, considering zootechnical performance, meat yield, and intestinal histomorphometry.
Joice Teixeira Souza, Maria Érica da Silva Oliveira, Ana Elidarly da Cunha, Vanessa Maria Freitas da Silva, Ruan Arthur Nunes de Araújo, Mário Augusto Monteiro Silva, Raimundo Audei Henrique Júnior, Marcos Aurelio Victor de Assunção, Ana Cecília Araújo Lopes, Daniel Pigatto Monteiro, Thiago Pereira Ribeiro, Moacir Franco de Oliveira, Matheus Ramalho de Lima   +12 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The effects of poneh essential oil (free and nonoliposomes forms) on chemical, biological and sensory characteristics of minced silver carp fish at 4 °C

سلامت و محیط, 2022
Background and Objective: Nowadays, the application of procedures to minimize oxidative and microbial spoilage in marine products is economically and hygienically important.
Neda Pouryousef, Mohammad Ahmady, Nabi Shariatifar, Sara Jafarian, Seyed-Ahmad Shahidi   +4 more
doaj  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Histological and microbiological alterations in sardines subjected to repeated freezethaw cycles: Implications for muscle integrity and food safety

Revista Científica
A total of thirty freshly caught sardines were subjected to one to five freeze–thaw cycles, while unfrozen samples served as controls. Muscle structure was assessed by histological and histomorphometric analyses, including measurements of vacuole area ...
Mounia Megaache, Nezar Adili, Hafsa Akkari, Omar Bennoune, Ferhat Nouicer   +4 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

The Effect of Combined Extracts from By-Products, Seaweed, and Pure Phenolics on the Quality of Vacuum-Packed Fish Burgers

Applied Sciences
The objective of the present study was to determine the effect of mixed plant extracts on chemical (pH, total volatile base nitrogen (TVB-N), trimethylamine nitrogen (TMA), thiobarbituric acid reactive substances (TBARS), biogenic amines, relative fatty ...
Vida Šimat, Danijela Skroza, Roberta Frleta Matas, Dilajla Radelić, Tanja Bogdanović, Martina Čagalj   +5 more
doaj   +1 more source