Results 71 to 80 of about 286,720 (300)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Evaluation of the Effectiveness of a Matrix of Exogenous Proteases in the Nutrition of Shrimp Penaeus vannamei

Animals
This study evaluated the effectiveness of a matrix of acid and alkaline proteases in diets for Penaeus vannamei shrimp, considering zootechnical performance, meat yield, and intestinal histomorphometry.
Joice Teixeira Souza, Maria Érica da Silva Oliveira, Ana Elidarly da Cunha, Vanessa Maria Freitas da Silva, Ruan Arthur Nunes de Araújo, Mário Augusto Monteiro Silva, Raimundo Audei Henrique Júnior, Marcos Aurelio Victor de Assunção, Ana Cecília Araújo Lopes, Daniel Pigatto Monteiro, Thiago Pereira Ribeiro, Moacir Franco de Oliveira, Matheus Ramalho de Lima   +12 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The effects of poneh essential oil (free and nonoliposomes forms) on chemical, biological and sensory characteristics of minced silver carp fish at 4 °C

سلامت و محیط, 2022
Background and Objective: Nowadays, the application of procedures to minimize oxidative and microbial spoilage in marine products is economically and hygienically important.
Neda Pouryousef, Mohammad Ahmady, Nabi Shariatifar, Sara Jafarian, Seyed-Ahmad Shahidi   +4 more
doaj  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Histological and microbiological alterations in sardines subjected to repeated freezethaw cycles: Implications for muscle integrity and food safety

Revista Científica
A total of thirty freshly caught sardines were subjected to one to five freeze–thaw cycles, while unfrozen samples served as controls. Muscle structure was assessed by histological and histomorphometric analyses, including measurements of vacuole area ...
Mounia Megaache, Nezar Adili, Hafsa Akkari, Omar Bennoune, Ferhat Nouicer   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Utilization of fish processing by-products for nutritional formulation of fish feed [PDF]

, 2003
Plan BSmall-scale fish farms market roughly 50 percent of the farm production. Processing of fish to produce fillets yields an immense quantity of underutilized by-products. Depending on the species, 30 to 80 percent by weight of the fish is not utilized
Maghaydah, Sofyan
core  

The Effect of Combined Extracts from By-Products, Seaweed, and Pure Phenolics on the Quality of Vacuum-Packed Fish Burgers

Applied Sciences
The objective of the present study was to determine the effect of mixed plant extracts on chemical (pH, total volatile base nitrogen (TVB-N), trimethylamine nitrogen (TMA), thiobarbituric acid reactive substances (TBARS), biogenic amines, relative fatty ...
Vida Šimat, Danijela Skroza, Roberta Frleta Matas, Dilajla Radelić, Tanja Bogdanović, Martina Čagalj   +5 more
doaj   +1 more source

Effects of Dietary Sodium Butyrate on Growth Performance, Immunity, Antioxidant Capacity and Appetite Regulation Factors of Juvenile Korean Rockfish Sebastes schlegelii [PDF]

Progress in Fishery Sciences
Butyric acid, as one of the short-chain fatty acids (SCFAs), is primarily produced through the fermentation of carbohydrates by gut microorganisms. Butyric acid exhibits functions such as promoting intestinal cell proliferation, regulating intestinal ...
Wang Peifeng, Li Baoshan, Wang Chengqiang, Li Qian, Wang Xiaoyan, Hao Tiantian, Li Lu, Sun Yongzhi   +7 more
doaj   +1 more source