Results 41 to 50 of about 433,957 (310)

Quantifying physiological influences on otolith microchemistry [PDF]

open access: yes, 2015
Trace element concentrations in fish earstones (‘otoliths’) are widely used to discriminate spatially discrete populations or individuals of marine fish, based on a commonly held assumption that physiological influences on otolith composition are minor ...
Hunter, Ewan   +5 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Conservation and sustainable utilization of Nigerian ornamental fishes [PDF]

open access: yes, 2005
The paper assessed qualitatively the threat status of nigerian freshwater fishes that are presently being exported and those that have potential in aquarium trade using such criteria as rarity, size at maturity, mode of reproduction, human population ...
Olaosebikan, B.D.
core  

Perturbations in growth trajectory due to early diet affect age-related deterioration in performance [PDF]

open access: yes, 2015
Fluctuations in early developmental conditions can cause changes in growth trajectories that subsequently affect the adult phenotype. Here, we investigated whether compensatory growth has long-term consequences for patterns of senescence.
Galloway T.F.   +8 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Integration of miRNA-mRNA co-expression network reveals potential regulation of miRNAs in hypothalamus from sterile triploid crucian carp

open access: yesReproduction and Breeding, 2021
The sterile triploid crucian carp (TC) has growth superiority which is generated from crossing between diploid red crucian carp (Carassius carassius red var. ♀) (RC) and tetraploid hybrid linage [derived from RC (♀) × common carp (Cyprinus carpio, ♂) (CC)
Yi Zhou   +9 more
doaj   +1 more source

A review of recent advances in commercial tilapia culture [PDF]

open access: yes, 1987
The paper introduces the tilapias as important culture fish; their classification, breeding habits and general ecology are discussed. The versatility and plasticity of their reproduction and growth are major advantages as well as draw backs in their use ...
Sagua, V.O.
core  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Preliminary Observations on spawning potential in the striped bass (Roccus saxatilis Walbaum) [PDF]

open access: yes, 1952
This study was initiated during the summer of 1940 with the following objectives: (1) To determine at what age sexual maturity begins in striped bass of the Chesapeake Bay.
Jackson, H.W., Tiller, R.E.
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

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