Results 71 to 80 of about 433,957 (310)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Artificial reproduction of Siganus sutor using LHRHα2 and HCG in Hormozgan Province, south of Iran [PDF]

, 2007
Feasibility of reproduction of rabbitfish, Siganus sutor, using LHRHα2 and HCG hormones were carried out during the years 2003 and 2004. Thirteen fishes were injected in April and May 2004 with LHRHα2 and HCG hormones used for males and females ...
Fourooghifard, H., Gharavi, B., Tazikeh, E., Zarshenas, Gh.A.   +3 more
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

First observation of facultative paedomorphosis in the Danube crested newt (Triturus dobrogicus Kiritzescu, 1903) and the occurrence of facultative paedomorphosis in two newt species from soda pans of the Danube-Tisza Interfluve (Kiskunság National Park, Hungary) [PDF]

, 2013
The first observation of paedomorphosis in Triturus dobrogicus and the occurrence of facultative paedomorphosis in two newt species (T.dobrogicus and Lissotriton vulgaris) from soda pans of the Danube- Tisza Interfluve, Hungary are reported in this ...
Cozma, Nastasia Julianna, Mester, Béla, Puky, Miklós   +2 more
core  

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Full-Length Transcriptome Reveals Heterologous Sperm Fragments in Natural Gynogenetic Grass Carp

Fishes
Grass carp (Ctenopharyngodon idella) is one of the most economically important cyprinid species cultured in China. The diploid gynogenetic grass carp (2nGGC, 2n = 48) was generated from the hybrid of female grass carp (GC, 2n = 48) and male topmouth ...
Lang Qin, Yuxiang Wang, Ming Wen, Jinhui Huang, Xu Huang, Qian Chen, Dan Peng, Yang Wu, Qianye Wei, Fangzhou Hu, Kaijun Gong, Chun Zhang, Qinbo Qin, Chang Wu, Shaojun Liu   +14 more
doaj   +1 more source

Decline in condition of northern bluefin tuna (Thunnus thynnus) in the Gulf of Maine [PDF]

, 2007
The northern bluefin tuna (Thunnus thynnus) is a highly mobile apex predator in the Gulf of Maine. Despite current stock assessments that indicate historically high abundance of its main prey, Atlantic herring (Clupea harengus), commercial fishermen have
Campbell , Robert, Cooper, Andrew B., Golet, Walter J., Lutcavage, Molly   +3 more
core  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Identification of Three POMCa Genotypes in Largemouth Bass (Micropterus salmoides) and Their Differential Physiological Responses to Feed Domestication

Animals
Diverse feeding habits in teleosts involve a wide range of appetite-regulating factors. As an appetite-suppressing gene, the polymorphisms of POMCa in largemouth bass (Micropterus salmoides) were validated via sequencing and high-resolution melting (HRM).
Jie Hu, Jie Yang, Huan Zhong, Qifang Yu, Jun Xiao, Chun Zhang   +5 more
doaj   +1 more source