Results 61 to 70 of about 1,654,556 (276)

Surveying the welfare of farmed fish species on a global scale through the fair-fish database

Fish welfare is a critical issue that needs to be addressed by the rapidly growing aquaculture industry. Scientific knowledge regarding the natural behaviors of species and the conditions in which they are kept in farms is essential for improving their ...
Volstorf, Jenny, Maia, Caroline Marques [UNESP], Gonçalves-de-Freitas, Eliane [UNESP], Saraiva, João Luis   +3 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Double Standards Regarding Animals as Silent Agents in Legislation: The Case of Wild Fish Welfare in Finland

Journal of Animal Law, Ethics and One Health
Fishing is one of the most widespread forms of wild animal use, yet welfare norms governing this practice remain limited. Recent legislation in Finland aims to improve fish welfare, with both the new Animal Welfare Act (AWA), effective from 2024, and ...
Saara Kupsala, Anna Valros, Laura Hänninen, Helena Röcklinsberg   +3 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Laterality and fish welfare

Applied Animal Behaviour Science, 2021
Humans interact with fishes in many contexts including aquaculture, scientific study and companion animals. In all of these contexts, fish welfare can be compromised through anthropogenic means. Concern for fish welfare has grown considerably in recent years, with many states and territories now protecting fish through animal welfare regulations.
Berlinghieri, Flavia, Panizzon, Paolo, Penry-Williams, Iestyn Lloyd, Brown, Culum   +3 more
openaire   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Fish welfare: an NGO’s point of view

Derecho Animal, 2019
Fish are the most exploited, forgotten and misunderstood animals on the planet. They also are extraordinary creatures: complex, intelligent, sensitive, curious, and some of them have amazing abilities. For instance; some use tools, have a good memory, or
Elena Lara, Natasha Boyland
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Fish welfare

Los peces son los animales más explotados, olvidados e incomprendidos del planeta. Pero también son criaturas extraordinarias: complejos, inteligentes, sensibles, curiosos, y algunos de ellos tienen habilidades increíbles. Por ejemplo, algunos usan herramientas, tienen buena memoria o colaboran para cazar.
M. Jones, K.A. Sloman
openaire   +3 more sources

Do fish have rights in artisanal fisheries?

Journal of Tropical Life Science, 2013
Artisanal fishers in developing world are unaware that fish are capable of suffering or discomfort, though researches have shown that fish do feel pain.
Mustapha MK
doaj