Results 131 to 140 of about 352,929 (356)

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti   +8 more
wiley   +1 more source

Simulation of fishery energy consumption and carbon emissions in Zhoushan City based on the long-range energy alternatives planning system model

open access: yesFrontiers in Energy Research
To understand the current situation and development trend of energy consumption and carbon emissions in the fishery industry, a Long-Range Energy Alternatives Planning System (LEAP)-fishery model for Zhoushan City was constructed, and the trends of ...
Xieqin Xu, Feng Gui, Sheng Zhao
doaj   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

A study of mercury concentration in organs of Zander fish (Sander lucioperca) in the Caspian Sea

open access: yes‬‭Majallah-i ̒Ilmī-i Shīlāt-i Īrān, 2008
We studied mercury bioaccumulation in liver, gill, skin and muscle of Zander fish and its relationships with weight, age and sex factors and compared the results with world standard levels.
L. Taheriazad; A. Esmaeili sari; K. Rezaei
doaj  

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

open access: yesMolecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita   +1 more
wiley   +1 more source

The change of environmental factors in the water near the Yangtze Estuary may induce the change of large yellow croaker fishery location there

open access: yesFrontiers in Marine Science
The large yellow croaker, an endemic migratory species in China’s coastal waters, holds considerable economic importance. It is very necessary and significant to study the spatio-temporal evolution of large yellow croaker fishery based on environmental ...
Lina Cai   +5 more
doaj   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

open access: yesMolecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi   +5 more
wiley   +1 more source

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